Inhibition of Mutated, Activated BRAF in Metastatic Melanoma (Q27860458)

2

0 references

Grant McArthur

Grant A McArthur

5

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Keith Flaherty

1

Keith T Flaherty

0 references

Keith Nolop

10

Keith Nolop

0 references

Jeffrey A Sosman

6

Jeffrey A Sosman

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author name string

Kevin B Kim

3

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Peter J O'Dwyer

7

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Richard J Lee

8

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Joseph F Grippo

9

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Paul B Chapman

The New England Journal of Medicine

11

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language of work or name

English

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publication date

26 August 2010

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published in

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volume

363

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page(s)

809-19

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issue

9

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on focus list of Wikimedia project

ScienceSource

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cites work

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

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Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

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Distinct sets of genetic alterations in melanoma

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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

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High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993

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Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma

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Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group

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BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas

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DTIC (NSC-45388) in malignant melanoma: a perspective

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Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors.

29 September 2017

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Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group

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BRAF mutations in papillary carcinomas of the thyroid

27 November 2018

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BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair

27 November 2018

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Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma

27 November 2018

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High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma

27 November 2018

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27 November 2018

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Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20818844

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

BRAF Mutation in Papillary Thyroid Carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20818844

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20818844