MicroRNAs: genomics, biogenesis, mechanism, and function (Q27861070)

https://doi.org/10.1016%2FS0092-8674%2804%2900045-5

miRNA-mediated gene silencing by inhibition of translation

22 April 2017

main subject

1 reference

pre-miRNA export from nucleus

GO:0035278

1 reference

mRNA destabilization-mediated gene silencing by miRNA

GO:0035281

1 reference

GO:0035279

gene silencing by miRNA

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small RNA loading onto RISC

GO:0035195

1 reference

1 reference

1 reference

1

David P Bartel

1 reference

https://doi.org/10.1016%2FS0092-8674%2804%2900045-5

22 April 2017

language of work or name

English

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publication date

23 January 2004

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January 2004

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https://doi.org/10.1016%2FS0092-8674%2804%2900045-5

22 April 2017

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https://doi.org/10.1016%2FS0092-8674%2804%2900045-5

22 April 2017

volume

116

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https://doi.org/10.1016%2FS0092-8674%2804%2900045-5

22 April 2017

page(s)

281-97

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281-297

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https://doi.org/10.1016%2FS0092-8674%2804%2900045-5

22 April 2017

issue

2

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https://doi.org/10.1016%2FS0092-8674%2804%2900045-5

The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs.

22 April 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A uniform system for microRNA annotation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

MicroRNAs and other tiny endogenous RNAs in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The small RNA profile during Drosophila melanogaster development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

MicroRNAs: at the root of plant development?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Human let-7 stem-loop precursors harbor features of RNase III cleavage products

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Role for a bidentate ribonuclease in the initiation step of RNA interference

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

AGO1 defines a novel locus of Arabidopsis controlling leaf development.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

HASTY, the Arabidopsis ortholog of exportin 5/MSN5, regulates phase change and morphogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Gene silencing in worms and fungi

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A micrococcal nuclease homologue in RNAi effector complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Mutations that lead to reiterations in the cell lineages of C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

MicroRNAs modulate hematopoietic lineage differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

siRNAs can function as miRNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Numerous microRNPs in neuronal cells containing novel microRNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Killing the messenger: short RNAs that silence gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

RNA interference is mediated by 21- and 22-nucleotide RNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Radial patterning of Arabidopsis shoots by class III HD-ZIP and KANADI genes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

MicroRNA targets in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Computational and experimental identification of C. elegans microRNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The microRNA Registry

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Establishment and maintenance of a heterochromatin domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A species of small antisense RNA in posttranscriptional gene silencing in plants

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Two classes of short interfering RNA in RNA silencing

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Argonaute2, a link between genetic and biochemical analyses of RNAi

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Embryonic stem cell-specific MicroRNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A microRNA in a multiple-turnover RNAi enzyme complex

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Expression profiling reveals off-target gene regulation by RNAi

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA unction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Retraction Note to: Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Functional siRNAs and miRNAs Exhibit Strand Bias

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A microRNA array reveals extensive regulation of microRNAs during brain development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The power of the 3' UTR: translational control and development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Identification of novel genes coding for small expressed RNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Identification of tissue-specific microRNAs from mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

New microRNAs from mouse and human

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

An extensive class of small RNAs in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

MicroRNA maturation: stepwise processing and subcellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The nuclear RNase III Drosha initiates microRNA processing

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Prediction of mammalian microRNA targets

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Induction and suppression of RNA silencing by an animal virus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The microRNAs of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Vertebrate microRNA genes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Endogenous and silencing-associated small RNAs in plants

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Nuclear export of microRNA precursors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Role of PHABULOSA and PHAVOLUTA in determining radial patterning in shoots

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Transcriptional silencing and promoter methylation triggered by double-stranded RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Short RNAs can identify new candidate transposable element families in Arabidopsis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

ATP requirements and small interfering RNA structure in the RNA interference pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Control of leaf morphogenesis by microRNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Evidence for nuclear processing of plant micro RNA and short interfering RNA precursors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Quelling in Neurospora crassa

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Nucleotide sequence homology requirements of HIV-1-specific short hairpin RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Small RNAs correspond to centromere heterochromatic repeats

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

1 reference

7 January 2021

Prediction of plant microRNA targets

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

DICER-LIKE1: blind men and elephants in Arabidopsis development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Asymmetry in the assembly of the RNAi enzyme complex

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Identification of Drosophila MicroRNA targets

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The rde-1 gene, RNA interference, and transposon silencing in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

A biochemical framework for RNA silencing in plants

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

RNA silencing in plants--defense and counterdefense

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Activation tagging in Arabidopsis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Negative feedback regulation of Dicer-Like1 in Arabidopsis by microRNA-guided mRNA degradation.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Structure and conserved RNA binding of the PAZ domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Sequence requirements for micro RNA processing and function in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021

ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2804%2900045-5

7 January 2021