The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. (Q27932308)

Gene Ontology release 2020-05-02

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0000408

mitochondrial tRNA threonylcarbamoyladenosine modification

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0072670

Threonylcarbamoyladenylate synthase YGL169W

1 reference

Chromatin DNA-binding EKC/KEOPS complex subunit PCC1 YKR095W-A

1 reference

Serine/threonine protein kinase BUD32 YGR262C

1 reference

Putative N(6)-L-threonylcarbamoyladenine synthase YDL104C

1 reference

TRNA N6-adenosine threonylcarbamoyltransferase YKR038C

1 reference

author

Eugene Koonin

5

0 references

Rolf Sternglanz

7

0 references

author name string

Madhusudhan Srinivasan

1

0 references

Preeti Mehta

2

0 references

Yao Yu

3

0 references

Evelyn Prugar

4

0 references

A Wali Karzai

The Sua5 protein is essential for normal translational regulation in yeast

6

0 references

language of work or name

English

0 references

publication date

2 March 2011

0 references

1 reference

1 December 2016

30

0 references

issue

5

0 references

page(s)

873-81

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine

20 March 2017

1 reference

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Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae

20 March 2017

1 reference

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An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro

20 March 2017

1 reference

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Yeast homolog of a cancer-testis antigen defines a new transcription complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Analysis of the interaction between piD261/Bud32, an evolutionarily conserved protein kinase of Saccharomyces cerevisiae, and the Grx4 glutaredoxin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Functional anticodon architecture of human tRNALys3 includes disruption of intraloop hydrogen bonding by the naturally occurring amino acid modification, t6A

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Programmed translational frameshifting in a gene required for yeast telomere replication

20 March 2017

1 reference

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Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches

20 March 2017

1 reference

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New variants of known folds: do they bring new biology?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Conserved network of proteins essential for bacterial viability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

'Conserved hypothetical' proteins: prioritization of targets for experimental study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Structure-function analysis of yeast piD261/Bud32, an atypical protein kinase essential for normal cell life

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Genome alignment, evolution of prokaryotic genome organization, and prediction of gene function using genomic context

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Novel families of putative protein kinases in bacteria and archaea: evolution of the "eukaryotic" protein kinase superfamily

29 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

29 September 2017

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.343

inferred from DOI database lookup

7 January 2021

based on heuristic

Cloning and nucleotide sequencing of the genes rimI and rimJ which encode enzymes acetylating ribosomal proteins S18 and S5 of Escherichia coli K12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

Effect of threonylcarbamoyl modification (t6A) in yeast tRNA Arg III on codon-anticodon and anticodon-anticodon interactions. A thermodynamic and kinetic evaluation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

The enzymatic synthesis of N-(purin-6-ylcarbamoyl)threonine, an anticodon-adjacent base in transfer ribonucleic acid

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

N-(purin-6-ylcarbamoyl)threonine: Biosynthesis in vitro in transfer RNA by an enzyme purified fromEscherichia coli

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049205

A genome-based approach for the identification of essential bacterial genes.

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.343

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.343

The role of modifications in codon discrimination by tRNA(Lys)UUU.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.343

Accurate translation of the genetic code depends on tRNA modified nucleosides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.343

Preparation and enzymatic hydrolysis of DNA and RNA for mass spectrometry

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21183954

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2010.343

1 reference

release_na5ng527tbaj7boqcjvicwc7cy

3307782

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/na5ng527tbaj7boqcjvicwc7cy

mapped directly with Wikidata item

24 November 2022

based on heuristic

3307782

1 reference

1 reference

1 reference