Defining the glycan destruction signal for endoplasmic reticulum-associated degradation (Q27932810)

Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation

GOA release 2020-03-11

author

Jimena Weibezahn

object named as

Jimena Weibezahn

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author name string

Erin M Quan

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Yukiko Kamiya

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Daiki Kamiya

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Vladimir Denic

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Koichi Kato

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Jonathan S Weissman

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language of work or name

English

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publication date

26 December 2008

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1 reference

1 December 2016

32

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cites work

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The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

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Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD.

20 March 2017

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Yos9p detects and targets misfolded glycoproteins for ER-associated degradation

20 March 2017

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Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen

20 March 2017

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Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein

20 March 2017

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Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

20 March 2017

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Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding

20 March 2017

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Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast

20 March 2017

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Mnl1p, an alpha -mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins

20 March 2017

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

20 March 2017

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Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation

20 March 2017

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A regulatory link between ER-associated protein degradation and the unfolded-protein response

20 March 2017

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Ordered assembly of the asymmetrically branched lipid-linked oligosaccharide in the endoplasmic reticulum is ensured by the substrate specificity of the individual glycosyltransferases

20 March 2017

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Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure

20 March 2017

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Role of the cysteine residues in the alpha1,2-mannosidase involved in N-glycan biosynthesis in Saccharomyces cerevisiae. The conserved Cys340 and Cys385 residues form an essential disulfide bond

20 March 2017

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N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast

20 March 2017

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Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast

20 March 2017

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Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity

20 March 2017

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Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

20 March 2017

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In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases

20 March 2017

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EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming

20 March 2017

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Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

20 March 2017

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Roles of N-linked glycans in the endoplasmic reticulum

7 April 2017

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Intracellular functions of N-linked glycans

7 April 2017

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Degradation of CFTR by the ubiquitin-proteasome pathway

7 April 2017

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The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum

7 April 2017

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Protein quality control in the early secretory pathway

29 September 2017

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Molecular basis of sugar recognition by the human L-type lectins ERGIC-53, VIPL, and VIP36.

29 September 2017

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The EDEM and Yos9p families of lectin-like ERAD factors

29 September 2017

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EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

29 September 2017

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Endoplasmic reticulum-associated degradation

29 September 2017

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Sugar-binding properties of VIP36, an intracellular animal lectin operating as a cargo receptor

29 September 2017

1 reference

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A window of opportunity: timing protein degradation by trimming of sugars and ubiquitins

29 September 2017

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The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tags

29 September 2017

1 reference

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Minor folding defects trigger local modification of glycoproteins by the ER folding sensor GT

29 September 2017

1 reference

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The biological and chemical basis for tissue-selective amyloid disease

29 September 2017

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Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

Endoplasmic reticulum-associated degradation of mammalian glycoproteins involves sugar chain trimming to Man6-5GlcNAc2.

29 September 2017

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Elucidation of the molecular logic by which misfolded alpha 1-antitrypsin is preferentially selected for degradation.

29 September 2017

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Enhancement of endoplasmic reticulum (ER) degradation of misfolded Null Hong Kong alpha1-antitrypsin by human ER mannosidase I.

29 September 2017

1 reference

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The action of molecular chaperones in the early secretory pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

Structure and function of Class I alpha 1,2-mannosidases involved in glycoprotein synthesis and endoplasmic reticulum quality control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

Conformational requirements for glycoprotein reglucosylation in the endoplasmic reticulum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

Processing of N-linked glycans during endoplasmic-reticulum-associated degradation of a short-lived variant of ribophorin I.

29 September 2017

1 reference

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The MRH domain suggests a shared ancestry for the mannose 6-phosphate receptors and other N-glycan-recognising proteins

2 June 2018

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The UDP-Glc:glycoprotein glucosyltrasferase is a soluble protein of the endoplasmic reticulum

2 June 2018

1 reference

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Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

DER7, encoding alpha-glucosidase I is essential for degradation of malfolded glycoproteins of the endoplasmic reticulum

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

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27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2873636

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation

27 November 2018

1 reference

12 December 2020

Recognition of local glycoprotein misfolding by the ER folding sensor UDP-glucose:glycoprotein glucosyltransferase

1 reference

12 December 2020

Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway

1 reference

12 December 2020

Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast

1 reference

12 December 2020

Importance of carbohydrate positioning in the recognition of mutated CPY for ER-associated degradation

1 reference

12 December 2020

Frontal affinity chromatography: theory for its application to studies on specific interactions of biomolecules

1 reference

12 December 2020