Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae (Q27934330)

GOA release 2020-03-11

1 reference

4

Jonathan S Weissman

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author name string

Françoise M Roelants

1

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David K Breslow

2

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Alexander Muir

3

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Jeremy Thorner

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

29 November 2011

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published in

1 reference

1 December 2016

108

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issue

48

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page(s)

19222-7

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cites work

Orm family proteins mediate sphingolipid homeostasis

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A protein kinase network regulates the function of aminophospholipid flippases

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A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling

20 March 2017

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Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry.

20 March 2017

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Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

20 March 2017

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Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity

20 March 2017

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Functional profiling of the Saccharomyces cerevisiae genome

20 March 2017

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Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast

20 March 2017

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The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast

20 March 2017

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Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast

20 March 2017

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Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

20 March 2017

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The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant

20 March 2017

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The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis

20 March 2017

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

20 March 2017

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Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin

20 March 2017

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The nuts and bolts of AGC protein kinases

20 March 2017

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Target of rapamycin (TOR) in nutrient signaling and growth control

7 April 2017

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mTOR complex 2 signaling and functions

29 September 2017

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Mitotic exit control of the Saccharomyces cerevisiae Ndr/LATS kinase Cbk1 regulates daughter cell separation after cytokinesis

29 September 2017

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Functions of phospholipid flippases

29 September 2017

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Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses

29 September 2017

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Keeping sphingolipid levels nORMal

29 September 2017

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An emerging role of mTOR in lipid biosynthesis.

29 September 2017

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The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease

29 September 2017

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Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast

29 September 2017

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Regulation of ceramide biosynthesis by TOR complex 2.

29 September 2017

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Flippases and vesicle-mediated protein transport

29 September 2017

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Loss of ypk1 function causes rapamycin sensitivity, inhibition of translation initiation and synthetic lethality in 14-3-3-deficient yeast

29 September 2017

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Magic bullets for protein kinases

29 September 2017

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Lipidomics: coming to grips with lipid diversity

29 September 2017

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Mutations in the C-terminus of the conserved NDR kinase, Cbk1p of Saccharomyces cerevisiae, make the protein independent of upstream activators.

27 November 2018

1 reference

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Separation and detection of large phosphoproteins using Phos-tag SDS-PAGE.

27 November 2018

1 reference

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The pharmacology of mTOR inhibition

27 November 2018

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The requirement for the hydrophobic motif phosphorylation of Ypk1 in yeast differs depending on the downstream events, including endocytosis, cell growth, and resistance to a sphingolipid biosynthesis inhibitor, ISP-1.

27 November 2018

1 reference

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Differential roles of PDK1- and PDK2-phosphorylation sites in the yeast AGC kinases Ypk1, Pkc1 and Sch9.

27 November 2018

1 reference

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