An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3'--&gt;5' degradation (Q27936597)

Gene Ontology release 2020-05-02

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ATP-dependent RNA helicase NAM7 YMR080C

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Exosome non-catalytic core subunit SKI6 YGR195W

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SKI complex RNA helicase subunit SKI2 YLR398C

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Functions of the exosome in rRNA, snoRNA and snRNA synthesis

author

David Tollervey

series ordinal

2

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author name string

Philip Mitchell

series ordinal

1

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language of work or name

English

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publication date

May 2003

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1 December 2016

11

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issue

5

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page(s)

1405-13

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cites work

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Degradation of ribosomal RNA precursors by the exosome

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Upf1 and Upf2 proteins mediate normal yeast mRNA degradation when translation initiation is limited

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

An essential component of the decapping enzyme required for normal rates of mRNA turnover

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Computational modeling and experimental analysis of nonsense-mediated decay in yeast

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3' end formation of 5.8S rRNA in Saccharomyces cerevisiae

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

mRNA decay enzymes: decappers conserved between yeast and mammals

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Site specific enzymatic cleavage of RNA

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

An mRNA surveillance mechanism that eliminates transcripts lacking termination codons

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

The Y14 protein communicates to the cytoplasm the position of exon-exon junctions

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Identification of an additional gene required for eukaryotic nonsense mRNA turnover

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Gene products that promote mRNA turnover in Saccharomyces cerevisiae

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Premature translational termination triggers mRNA decapping

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Binary specification of nonsense codons by splicing and cytoplasmic translation

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Mechanisms and control of mRNA decapping in Saccharomyces cerevisiae

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Exosome-mediated recognition and degradation of mRNAs lacking a termination codon

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Functional link between the mammalian exosome and mRNA decapping

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

An internal open reading frame triggers nonsense-mediated decay of the yeast SPT10 mRNA.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation

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https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021

Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900190-4

7 January 2021