Predominately Uncultured Microbes as Sources of Bioactive Agents (Q28073712)

language of work or name

1 reference

18 November 2016

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Frontiers in Microbiology

published in

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volume

7

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page(s)

1832

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Synthetic biology to access and expand nature's chemical diversity

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Endosymbiont-Dependent Host Reproduction Maintains Bacterial-Fungal Mutualism

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Are you my symbiont? Microbial polymorphic toxins and antimicrobial compounds as honest signals of beneficial symbiotic defensive traits

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Advanced tools in marine natural drug discovery

29 September 2017

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Calyculin: Nature's way of making the sponge-derived cytotoxin

29 September 2017

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New strategy for drug discovery by large-scale association analysis of molecular networks of different species

29 September 2017

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Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway

29 September 2017

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Increasing the Richness of Culturable Arsenic-Tolerant Bacteria from Theonella swinhoei by Addition of Sponge Skeleton to the Growth Medium

29 September 2017

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29 September 2017

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Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria

29 September 2017

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Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B.

29 September 2017

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Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products.

29 September 2017

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Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks

29 September 2017

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Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

29 September 2017

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Discovery of microbial natural products by activation of silent biosynthetic gene clusters

29 September 2017

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29 September 2017

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Mapping Microbial Response Metabolomes for Induced Natural Product Discovery.

29 September 2017

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Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743.

29 September 2017

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Mass spectrometry tools and workflows for revealing microbial chemistry

29 September 2017

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29 September 2017

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Hexacyclopeptides secreted by an endophytic fungus Fusarium solani N06 act as crosstalk molecules in Narcissus tazetta

29 September 2017

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Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms.

29 September 2017

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Simple "on-demand" production of bioactive natural products

29 September 2017

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Plants and endophytes: equal partners in secondary metabolite production?

29 September 2017

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Endophytes are hidden producers of maytansine in Putterlickia roots

29 September 2017

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Latitudinal variation of a defensive symbiosis in the Bugula neritina (Bryozoa) sibling species complex

29 September 2017

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Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics

29 September 2017

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Active invasion of bacteria into living fungal cells

29 September 2017

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Species specificity of symbiosis and secondary metabolism in ascidians

29 September 2017

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Multi-well fungal co-culture for de novo metabolite-induction in time-series studies based on untargeted metabolomics

29 September 2017

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An environmental bacterial taxon with a large and distinct metabolic repertoire

29 September 2017

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Fungal endophytes - secret producers of bioactive plant metabolites

29 September 2017

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Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses.

29 September 2017

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Molecular bacteria-fungi interactions: effects on environment, food, and medicine

29 September 2017

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Metagenomic approaches for exploiting uncultivated bacteria as a resource for novel biosynthetic enzymology.

29 September 2017

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Dermatitis linearis: vesicating dermatosis caused by paederus species (coleoptera: staphylinidae). Case series and review

29 September 2017

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Genome streamlining and chemical defense in a coral reef symbiosis.

29 September 2017

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Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin

29 September 2017

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Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes

29 September 2017

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Isolation, biological activity, synthesis, and medicinal chemistry of the pederin/mycalamide family of natural products

29 September 2017

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Origin and variation of tunicate secondary metabolites

29 September 2017

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Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis

29 September 2017

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Ribosomal route to small-molecule diversity

29 September 2017

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Extreme genome reduction in symbiotic bacteria

29 September 2017

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Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs

29 September 2017

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Novel oligonucleotide probes for in situ detection of pederin-producing endosymbionts of Paederus riparius rove beetles (Coleoptera: Staphylinidae).

29 September 2017

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Total synthesis of pederin and analogues

29 September 2017

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Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase

29 September 2017

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Epigenome manipulation as a pathway to new natural product scaffolds and their congeners

29 September 2017

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Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger.

29 September 2017

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Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem.

29 September 2017

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In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.

29 September 2017

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Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner

29 September 2017

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Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina

29 September 2017

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Synthesis of psymberin analogues: probing a functional correlation with the pederin/mycalamide family of natural products

29 September 2017

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A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina", the bacterial endosymbiont of the fungus Rhizopus microsporus

29 September 2017

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Bacterial symbionts: prospects for the sustainable production of invertebrate-derived pharmaceuticals

29 September 2017

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Libertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competition

29 September 2017

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Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production

29 September 2017

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Exploring the chemistry of uncultivated bacterial symbionts: antitumor polyketides of the pederin family

29 September 2017

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Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei

29 September 2017

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Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family

29 September 2017

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Evidence for a symbiosis island involved in horizontal acquisition of pederin biosynthetic capabilities by the bacterial symbiont of Paederus fuscipes beetles

29 September 2017

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Antineoplastic agents. 520. Isolation and structure of irciniastatins A and B from the Indo-Pacific marine sponge Ircinia ramosa.

29 September 2017

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Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5114300

Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5114300

Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5114300

Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the bryozoan Bugula neritina

29 September 2017

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Identification of sibling species of the bryozoan Bugula neritina that produce different anticancer bryostatins and harbor distinct strains of the bacterial symbiont "Candidatus Endobugula sertula".

29 September 2017

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Small-subunit rRNA genes and in situ hybridization with oligonucleotides specific for the bacterial symbionts in the larvae of the bryozoan Bugula neritina and proposal of "Candidatus endobugula sertula".

29 September 2017

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Biosynthesis of antifungal and antibacterial polyketides by Burkholderia gladioli in coculture with Rhizopus microsporus

29 September 2017

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Molecular characterization of the safracin biosynthetic pathway from Pseudomonas fluorescens A2-2: designing new cytotoxic compounds

2 June 2018

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Naphthyridinomycin, a new broad-spectrum antibiotic

2 June 2018

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New antibiotics saframycins A, B, C, D and E.

2 June 2018

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Diminution of the antibacterial activity of antibiotics in cultures and in experimental mixed infections

2 June 2018

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A mixed culture of endophytic fungi increases production of antifungal polyketides

2 June 2018

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Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum).

21 January 2018

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A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger.

21 January 2018

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Suppression of pederin biosynthesis through antibiotic elimination of endosymbionts in Paederus sabaeus

21 January 2018

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Molecular identification of an endosymbiotic bacterium associated with pederin biosynthesis in Paederus sabaeus (Coleoptera: Staphylinidae).

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Synthesis of Natural Ecteinascidins (ET-729, ET-745, ET-759B, ET-736, ET-637, ET-594) from Cyanosafracin B

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Radical S-adenosyl methionine epimerases: regioselective introduction of diverse D-amino acid patterns into peptide natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Bacterial diversity associated with the Caribbean tunicate Ecteinascidia turbinata.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Privileged structures as leads in medicinal chemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Localization of 'Candidatus Endobugula sertula' and the bryostatins throughout the life cycle of the bryozoan Bugula neritina

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Application of diffusion growth chambers for the cultivation of marine sponge-associated bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Onnamide F: a new nematocide from a southern Australian marine sponge, Trachycladus laevispirulifer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Total Synthesis of Pederin

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Protective tunicate endosymbiont with extreme genome reduction

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Intracellular bacteria associated with the ascidian Ecteinascidia turbinata : phylogenetic and in situ hybridisation analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Saframycin Mx1, a new natural saframycin isolated from a myxobacterium

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5114300

Antiviral and antitumor agents from a New Zealand sponge, Mycale sp. 2. Structures and solution conformations of mycalamides A and B

27 November 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMICB.2016.01832

Microbial antagonism: a neglected avenue of natural products research

21 January 2018

1 reference

12 December 2020

Theopederins K and L. Highly potent cytotoxic metabolites from a marine sponge Discodermia species

1 reference

12 December 2020

Potent cytotoxins produced by a microbial symbiont protect host larvae from predation

1 reference

12 December 2020

Genomic mining for Aspergillus natural products

1 reference

12 December 2020

The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices

1 reference

12 December 2020

Symbiotic Cooperation in the Biosynthesis of a Phytotoxin

1 reference

12 December 2020

Natural products: Hunting microbial metabolites

1 reference

12 December 2020

Dual Chemical Modification of a Polytheonamide Mimic: Rational Design and Synthesis of Ion-Channel-Forming 48-mer Peptides with Potent Cytotoxicity

1 reference

12 December 2020

Lithistid Sponges: Star Performers or Hosts to the Stars

1 reference

12 December 2020

The structure of a novel antitumor antibiotic, saframycin A

1 reference

12 December 2020

Secondary fungal metabolites and their biological activities, V. Investigations concerning the induction of the biosynthesis of toxic secondary metabolites in basidiomycetes

1 reference

12 December 2020