The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease (Q28087330)

Yulin Deng

series ordinal

2

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Hong Qing

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3

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language of work or name

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October 2015

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Journal of Neurochemistry

published in

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volume

135

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issue

1

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page(s)

4-18

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

cites work

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alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells

21 January 2018

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

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In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain

21 January 2018

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

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Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis

21 January 2018

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Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

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Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

21 January 2018

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Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

21 January 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

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Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein

21 January 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

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Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein

21 January 2018

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Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

21 January 2018

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Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

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alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases

21 January 2018

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Transgenic mice expressing S129 phosphorylation mutations in α-synuclein

21 January 2018

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LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis

21 January 2018

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Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease.

21 January 2018

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Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease.

21 January 2018

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

21 January 2018

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Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation

21 January 2018

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The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

21 January 2018

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Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

21 January 2018

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The Role of alpha-synuclein assembly and metabolism in the pathogenesis of Lewy body disease

21 January 2018

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Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.

21 January 2018

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

21 January 2018

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Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

21 January 2018

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Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

21 January 2018

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The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

21 January 2018

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Pathological biochemistry of alpha-synucleinopathy

21 January 2018

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Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation

21 January 2018

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Efficient modification of alpha-synuclein serine 129 by protein kinase CK1 requires phosphorylation of tyrosine 125 as a priming event

21 January 2018

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21 January 2018

Autophagy in dementias

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans

21 January 2018

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

21 January 2018

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Subjective complaints precede Parkinson disease: the rotterdam study

21 January 2018

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Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery

21 January 2018

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Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders

21 January 2018

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Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

21 January 2018

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Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons

21 January 2018

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Phosphorylation of synucleins by members of the Polo-like kinase family

21 January 2018

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Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra

21 January 2018

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Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions

21 January 2018

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Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

21 January 2018

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Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

21 January 2018

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Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.

21 January 2018

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Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.

21 January 2018

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Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

21 January 2018

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Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomers

21 January 2018

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Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?

21 January 2018

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Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

21 January 2018

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Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

21 January 2018

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Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.

21 January 2018

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Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

21 January 2018

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Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

21 January 2018

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Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells

21 January 2018

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Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Synucleins are a novel class of substrates for G protein-coupled receptor kinases

21 January 2018

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Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

21 January 2018

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Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context

21 January 2018

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Science, medicine, and the future: Parkinson's disease

21 January 2018

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A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.

21 January 2018

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The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

21 January 2018

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Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

21 January 2018

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Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

21 January 2018

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Alpha-synuclein in Lewy bodies

21 January 2018

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Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death

21 January 2018

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Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

21 January 2018

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Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation

21 January 2018

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Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease

21 January 2018

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Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease

21 January 2018

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Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

21 January 2018

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Explaining the structural plasticity of α-synuclein

21 January 2018

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Structure and dynamics of micelle-bound human alpha-synuclein

21 January 2018

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Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

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Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes.

21 January 2018

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Phosphorylated α-synuclein in Parkinson's disease

21 January 2018

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Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein

21 January 2018

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Characterization of kinases involved in the phosphorylation of aggregated α-synuclein

21 January 2018

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

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Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells

21 January 2018

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Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

21 January 2018

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α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

21 January 2018

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Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson

21 January 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

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Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody

21 January 2018

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Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease.

21 January 2018

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Tenuigenin attenuates α-synuclein-induced cytotoxicity by down-regulating polo-like kinase 3.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.13234

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PubMed publication ID

26134497

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