A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation (Q28114914)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9880516%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

title

A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation (English)

2 references

3 January 2017

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8 December 2019

6

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8 December 2019

author name string

M A Booden

1

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8 December 2019

T L Baker

2

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8 December 2019

P A Solski

3

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8 December 2019

C J Der

4

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8 December 2019

S G Punke

5

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8 December 2019

language of work or name

English

0 references

publication date

1 January 1999

1 reference

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Journal of Biological Chemistry

8 December 2019

published in

2 references

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8 December 2019

volume

274

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8 December 2019

issue

3

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8 December 2019

page(s)

1423-1431

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Protein prenylation: molecular mechanisms and functional consequences

8 December 2019

cites work

1 reference

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All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

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Direct identification of palmitic acid as the lipid attached to p21ras

21 January 2018

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Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

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Protein isoprenylation and methylation at carboxyl-terminal cysteine residues

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S-Acylation and plasma membrane targeting of the farnesylated carboxyl-terminal peptide of N-ras in mammalian fibroblasts

21 January 2018

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Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in Xenopus oocytes.

21 January 2018

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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

1 reference

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Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

21 January 2018

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Polylysine domain of K-ras 4B protein is crucial for malignant transformation

21 January 2018

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Evidence for a high affinity, saturable, prenylation-dependent p21Ha-ras binding site in plasma membranes

21 January 2018

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An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

21 January 2018

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Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

21 January 2018

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Ras membrane targeting is essential for glucose signaling but not for viability in yeast

21 January 2018

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The effect of posttranslational modifications on the interaction of Ras2 with adenylyl cyclase

21 January 2018

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G-protein palmitoyltransferase activity is enriched in plasma membranes

21 January 2018

1 reference

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N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization

21 January 2018

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Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal

21 January 2018

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Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43.

21 January 2018

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Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

21 January 2018

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Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes

21 January 2018

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Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

21 January 2018

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Activated N-ras gene induces neuronal differentiation of PC12 rat pheochromocytoma cells.

21 January 2018

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Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

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p21ras is modified by a farnesyl isoprenoid

21 January 2018

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Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

21 January 2018

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Derivatives of activated H-ras lacking C-terminal lipid modifications retain transforming ability if targeted to the correct subcellular location

21 January 2018

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Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation

21 January 2018

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A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions

21 January 2018

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Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

21 January 2018

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Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

21 January 2018

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Purification of a protein palmitoyltransferase that acts on H-Ras protein and on a C-terminal N-Ras peptide

21 January 2018

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Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange

21 January 2018

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Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger

21 January 2018

1 reference

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Biochemical characterization of a palmitoyl acyltransferase activity that palmitoylates myristoylated proteins

21 January 2018

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Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.3.1423

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9880516%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

2 references

3 January 2017