FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association (Q28115097)

GOA release 2020-03-11

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Y. Feng

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3 January 2017

D. Absher

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3 January 2017

D. E. Eberhart

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3 January 2017

V. Brown

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3 January 2017

H. E. Malter

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3 January 2017

S. T. Warren

FMR1 protein: conserved RNP family domains and selective RNA binding

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3 January 2017

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1 December 1997

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109–118

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3 January 2017

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Human and murine FMR-1: alternative splicing and translational initiation downstream of the CGG-repeat.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Antiribosomal S10 antibodies in humans and MRL/lpr mice with systemic lupus erythematosus

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Conserved structures and diversity of functions of RNA-binding proteins

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

The KH module has an αβ fold

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Reversal of creatine kinase translational repression by 3' untranslated sequences

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

A point mutation in the FMR-1 gene associated with fragile X mental retardation

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

hnRNP proteins and the biogenesis of mRNA

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Inducers of erythroleukemic differentiation cause messenger RNAs that lack poly(A)-binding protein to accumulate in translationally inactive, salt-labile 80 S ribosomal complexes.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Tissue-specific expression of a FMR1/beta-galactosidase fusion gene in transgenic mice.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Importance of polysomal mRNA-associated polypeptides for protein synthesis initiation in yeast.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Analysis of neocortex in three males with the fragile X syndrome

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

The fragile X mental retardation protein is associated with ribosomes

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Intragenic loss of function mutations demonstrate the primary role of FMR1 in fragile X syndrome

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

A deletion of 1.6 kb proximal to the CGG repeat of the FMR1 gene causes the clinical phenotype of the fragile X syndrome

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Three-dimensional structure and stability of the KH domain: molecular insights into the fragile X syndrome

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

The translation machinery and 70 kd heat shock protein cooperate in protein synthesis

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Adult fragile X syndrome. Clinico-neuropathologic findings.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

DNA methylation represses FMR-1 transcription in fragile X syndrome

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

FMRP is associated to the ribosomes via RNA.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Protein-rRNA binding features and their structural and functional implications in ribosomes as determined by cross-linking studies.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021

Advances in molecular analysis of fragile X syndrome

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2980012-X

7 January 2021