Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR (Q28119029)

4 January 2017

title

Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR (English)

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ELAV like RNA binding protein 1

4 January 2017

main subject

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protein homodimerization activity

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

Nicole-Claudia Meisner

1

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Martin Hintersteiner

2

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Kurt Mueller

3

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Roman Bauer

4

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Jan-Marcus Seifert

5

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Hans-Ulrich Naegeli

6

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Johannes Ottl

7

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Lukas Oberer

8

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Christian Guenat

9

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Serge Moss

10

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Nathalie Harrer

11

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Maximilian Woisetschlaeger

12

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Christof Buehler

13

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Volker Uhl

14

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Manfred Auer

15

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publication date

1 August 2007

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4 January 2017

published in

Nature Chemical Biology

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4 January 2017

volume

3

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issue

8

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4 January 2017

page(s)

508–515

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Detection of the anti-Hu antibody in specific regions of the nervous system and tumor from patients with paraneoplastic encephalomyelitis/sensory neuronopathy

4 January 2017

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Cytoplasmic HuR expression correlates with epithelial cancer cell but not with stromal cell cyclooxygenase-2 expression in mucinous ovarian carcinoma

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Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression

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Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma.

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Inhibitory activity of the human papillomavirus type 1 AU-rich element correlates inversely with the levels of the elav-like HuR protein in the cell cytoplasm

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Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2.

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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mRNA openers and closers: modulating AU-rich element-controlled mRNA stability by a molecular switch in mRNA secondary structure.

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The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression

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The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR.

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Complex formation of the neuron-specific ELAV-like Hu RNA-binding proteins

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Determination of binding stoichiometry by the continuous variation method: the Job plot

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Delineation of mRNA export pathways by the use of cell-permeable peptides

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7 January 2021

HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation

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7 January 2021

HuR regulates p21 mRNA stabilization by UV light

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7 January 2021

Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha

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7 January 2021

A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR.

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7 January 2021

Androgens regulate the binding of endogenous HuR to the AU-rich 3'UTRs of HIF-1alpha and EGF mRNA.

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7 January 2021

ATP potentiates interleukin-1 beta-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR.

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7 January 2021

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

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7 January 2021

MS-444, a New Inhibitor of Myosin Light Chain Kinase from Micromonospora sp. KY7123

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7 January 2021

Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase

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7 January 2021

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7 January 2021