TGF-beta signalling from cell membrane to nucleus through SMAD proteins (Q28131770)

TGF-beta signalling through the Smad pathway

Europe PubMed Central

title

TGF-beta signalling from cell membrane to nucleus through SMAD proteins (English)

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author name string

C H Heldin

series ordinal

1

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K Miyazono

series ordinal

2

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P ten Dijke

series ordinal

3

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language of work or name

English

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publication date

4 December 1997

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published in

Nature

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volume

390

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page(s)

465-71

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issue

6659

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cites work

1 reference

7 January 2021

Mechanism of activation of the TGF-beta receptor

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7 January 2021

The types II and III transforming growth factor-beta receptors form homo-oligomers

1 reference

7 January 2021

Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.

1 reference

7 January 2021

Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors

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7 January 2021

Activation of signalling by the activin receptor complex

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7 January 2021

Cooperative binding of transforming growth factor (TGF)-beta 2 to the types I and II TGF-beta receptors

1 reference

7 January 2021

Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs

1 reference

7 January 2021

Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors

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7 January 2021

Cloning and characterization of a human type II receptor for bone morphogenetic proteins

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7 January 2021

Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

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7 January 2021

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

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7 January 2021

A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity

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7 January 2021

Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1.

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7 January 2021

Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis

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7 January 2021

Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities.

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7 January 2021

Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues

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7 January 2021

The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues

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7 January 2021

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7 January 2021

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components

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7 January 2021

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily.

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7 January 2021

A human Mad protein acting as a BMP-regulated transcriptional activator

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7 January 2021

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

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7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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7 January 2021

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

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7 January 2021

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

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7 January 2021

Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins

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7 January 2021

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

1 reference

7 January 2021

Smad5 induces ventral fates in Xenopus embryo

1 reference

7 January 2021

Cloning and characterization of a novel member of the human Mad gene family (MADH6)

1 reference

7 January 2021

Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1

1 reference

7 January 2021

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth

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7 January 2021

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

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7 January 2021

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

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7 January 2021

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

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7 January 2021

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

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7 January 2021

Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

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7 January 2021

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

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7 January 2021

Genetic and biochemical analysis of TGF beta signal transduction

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7 January 2021

Characterization of functional domains within Smad4/DPC4

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7 January 2021

The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation.

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7 January 2021

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.

1 reference

7 January 2021

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic.

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7 January 2021

A structural basis for mutational inactivation of the tumour suppressor Smad4

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7 January 2021

Smad6 inhibits signalling by the TGF-beta superfamily.

1 reference

7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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7 January 2021

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7 January 2021

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium

1 reference

7 January 2021

Daughters against dpp modulates dpp organizing activity in Drosophila wing development.

1 reference

7 January 2021

Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse

1 reference

7 January 2021

Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1' in Xenopus laevis embryos.

1 reference

7 January 2021

Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1.

1 reference

7 January 2021

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex

1 reference

7 January 2021

Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter

1 reference

7 January 2021

Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site

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7 January 2021

A transcriptional partner for MAD proteins in TGF-beta signalling

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7 January 2021

Smad4 and FAST-1 in the assembly of activin-responsive factor

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7 January 2021

The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family

1 reference

7 January 2021

Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1.

1 reference

7 January 2021

FKBP-12 recognition is dispensable for signal generation by type I transforming growth factor-beta receptors.

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7 January 2021

The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.

1 reference

7 January 2021

Mechanism of TGFbeta receptor inhibition by FKBP12

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7 January 2021

Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor

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7 January 2021

Interaction of transforming growth factor-beta receptor I with farnesyl-protein transferase-alpha in yeast and mammalian cells

1 reference

7 January 2021

The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling

1 reference

7 January 2021

Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin

1 reference

7 January 2021

A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor

1 reference

7 January 2021

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

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7 January 2021

Altered transforming growth factor signaling in epithelial cells when ras activation is blocked

1 reference

7 January 2021

Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression

1 reference

7 January 2021

Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling

1 reference

7 January 2021

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

1 reference

7 January 2021

Tumor suppressor activity of the TGF-beta pathway in human cancers

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7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

7 January 2021

Mad-related genes in the human

1 reference

7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

7 January 2021

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15

1 reference

7 January 2021

Cdc25 cell-cycle phosphatase as a target of c-myc

1 reference

7 January 2021

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

1 reference

7 January 2021

STATs: signal transducers and activators of transcription

1 reference

7 January 2021

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

1 reference

7 January 2021

Identifiers

DOI

10.1038/37284

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

147026

1001112208

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147026

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference