Genetic instabilities in human cancers (Q28131826)

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

Europe PubMed Central

title

Genetic instabilities in human cancers (English)

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3

B Vogelstein

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Kenneth W. Kinzler

series ordinal

2

object named as

K W Kinzler

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author name string

C Lengauer

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1

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language of work or name

English

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publication date

17 December 1998

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published in

Nature

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volume

396

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issue

6712

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page(s)

643-9

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cites work

1 reference

7 January 2021

The mutation rate and cancer

1 reference

7 January 2021

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1 reference

7 January 2021

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

1 reference

7 January 2021

Genetic alterations in leukemias and lymphomas: impressive progress and continuing complexity

1 reference

7 January 2021

Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas

1 reference

7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

7 January 2021

DNA-mismatch repair. The intricacies of eukaryotic spell-checking

1 reference

7 January 2021

Genetic control of microsatellite stability

1 reference

7 January 2021

Defective Repair Replication of DNA in Xeroderma Pigmentosum

1 reference

7 January 2021

Genetic Heterogeneity of Xeroderma Pigmentosum demonstrated by Somatic Cell Hybridization

1 reference

7 January 2021

DNA repair in eukaryotes

1 reference

7 January 2021

The origin of human cancers

1 reference

7 January 2021

DNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum

1 reference

7 January 2021

Endogenous mutagens and the causes of aging and cancer

1 reference

7 January 2021

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction

1 reference

7 January 2021

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1 reference

7 January 2021

Microsatellite instability in cancer of the proximal colon

1 reference

7 January 2021

Clues to the pathogenesis of familial colorectal cancer

1 reference

7 January 2021

Genetic mapping of a locus predisposing to human colorectal cancer

1 reference

7 January 2021

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

1 reference

7 January 2021

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1 reference

7 January 2021

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1 reference

7 January 2021

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1 reference

7 January 2021

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

1 reference

7 January 2021

Mutation of a mutL homolog in hereditary colon cancer

1 reference

7 January 2021

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1 reference

7 January 2021

Mutations predisposing to hereditary nonpolyposis colorectal cancer

1 reference

7 January 2021

Mismatch repair, genetic stability and tumour avoidance

1 reference

7 January 2021

Biochemistry and genetics of eukaryotic mismatch repair

1 reference

7 January 2021

Mutator phenotypes in human colorectal carcinoma cell lines

1 reference

7 January 2021

Allelotype of colorectal carcinomas

1 reference

7 January 2021

Genetic instability in colorectal cancers

1 reference

7 January 2021

Loss of heterozygosity and base substitution at the APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines

1 reference

7 January 2021

Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer

1 reference

7 January 2021

Cytogenetic analysis of colorectal adenomas: karyotypic comparisons of synchronous tumors.

1 reference

7 January 2021

Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells

1 reference

7 January 2021

A p53-dependent mouse spindle checkpoint

1 reference

7 January 2021

Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

1 reference

7 January 2021

Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53

1 reference

7 January 2021

Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes

1 reference

7 January 2021

The genetics of cell cycle checkpoints

1 reference

7 January 2021

At the heart of the budding yeast cell cycle

1 reference

7 January 2021

Cell cycle checkpoints: preventing an identity crisis

1 reference

7 January 2021

When checkpoints fail

1 reference

7 January 2021

Mutations of mitotic checkpoint genes in human cancers

1 reference

7 January 2021

Identification of a human mitotic checkpoint gene: hsMAD2

1 reference

7 January 2021

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

1 reference

7 January 2021

Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

1 reference

7 January 2021

ATM: from gene to function

1 reference

7 January 2021

Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest

1 reference

7 January 2021

BRCA1, BRCA2, and DNA damage response: collision or collusion?

1 reference

7 January 2021

1 reference

7 January 2021

The centrosome--a tiny organelle with big potential

1 reference

7 January 2021

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1 reference

7 January 2021

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1 reference

7 January 2021

Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer

1 reference

7 January 2021

Abnormal centrosome amplification in the absence of p53.

1 reference

7 January 2021

Primary vs. secondary neoplasia-associated chromosomal abnormalities--balanced rearrangements vs. genomic imbalances?

1 reference

7 January 2021

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

1 reference

7 January 2021

Inactivation of p53 results in high rates of homologous recombination

1 reference

7 January 2021

T cell receptor gene trans-rearrangements: chimeric gamma-delta genes in normal lymphoid tissues

1 reference

7 January 2021

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

1 reference

7 January 2021

Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis

1 reference

7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

7 January 2021

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

1 reference

7 January 2021

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment

1 reference

7 January 2021

Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells

1 reference

7 January 2021

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

1 reference

7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

7 January 2021