From receptors to stress-activated MAP kinases (Q28137773)

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

Europe PubMed Central

title

From receptors to stress-activated MAP kinases (English)

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author name string

H Ichijo

series ordinal

1

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language of work or name

English

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publication date

1 November 1999

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published in

Oncogene

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volume

18

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issue

45

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page(s)

6087-93

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cites work

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Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

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Modulation of life and death by the TNF receptor superfamily

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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

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TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

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Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase

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Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha

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TRAF6 is a signal transducer for interleukin-1

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The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

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Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx

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Involvement of CRAF1, a relative of TRAF, in CD40 signaling

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Cloning and characterization of a human protein kinase with homology to Ste20

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MAPKs: new JNK expands the group

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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase

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Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2

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A conserved kinase cascade for MAP kinase activation in yeast.

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MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

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Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway

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Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

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Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction

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Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

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Selective interaction of JNK protein kinase isoforms with transcription factors

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase

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MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

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TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

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Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade

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Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta

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HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

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Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

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LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes

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Signaling by the germinal center kinase family of protein kinases

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Sounding the alarm: protein kinase cascades activated by stress and inflammation

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A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival

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The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2

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A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses

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The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

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The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3

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Apoptosis by death factor

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TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor

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Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

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Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation

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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

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ASK1 is essential for JNK/SAPK activation by TRAF2

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The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.

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Cloning of a novel putative protein kinase having a leucine zipper domain from human brain

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Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma

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Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2.

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A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

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TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

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Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

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Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

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MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

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Mitogen-activated protein kinases: specific messages from ubiquitous messengers

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Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements

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TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related

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TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

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The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

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Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

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Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade

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p38-2, a novel mitogen-activated protein kinase with distinct properties.

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NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

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A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways

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A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

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Newly identified stress-responsive protein kinases, Krs-1 and Krs-2

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Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

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A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase

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Tumor necrosis factor receptor and Fas signaling mechanisms.

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Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase

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Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase

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MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5

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Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

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Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

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A mammalian scaffold complex that selectively mediates MAP kinase activation

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Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

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Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase

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Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

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Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

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Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase

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A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway

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Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

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Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting [...]

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Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta

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