Genetic pathways that regulate ageing in model organisms (Q28138437)

The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake

Europe PubMed Central

title

Genetic pathways that regulate ageing in model organisms (English)

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1

L Guarente

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author name string

C Kenyon

series ordinal

2

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language of work or name

English

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publication date

9 November 2000

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published in

Nature

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volume

408

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page(s)

255-62

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issue

6809

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cites work

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7 January 2021

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7 January 2021

Life span of individual yeast cells

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7 January 2021

Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae

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7 January 2021

The genetics of aging in the yeast Saccharomyces cerevisiae

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Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae

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7 January 2021

Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription

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7 January 2021

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

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An unusual form of transcriptional silencing in yeast ribosomal DNA

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7 January 2021

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast

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7 January 2021

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.

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A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors

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7 January 2021

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

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7 January 2021

Extrachromosomal rDNA circles--a cause of aging in yeast

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Elimination of replication block protein Fob1 extends the life span of yeast mother cells.

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Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast

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Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae

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Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants

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7 January 2021

A yeast gene that is essential for release from glucose repression encodes a protein kinase

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7 January 2021

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

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7 January 2021

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

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7 January 2021

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation

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7 January 2021

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

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7 January 2021

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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7 January 2021

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

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7 January 2021

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

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Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

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Prolongation of the yeast life span by the v-Ha-RAS oncogene

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The mitochondrial genotype can influence nuclear gene expression in yeast.

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7 January 2021

Do changes in chromosomes cause aging?

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7 January 2021

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7 January 2021

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

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7 January 2021

A C. elegans mutant that lives twice as long as wild type

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7 January 2021

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

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7 January 2021

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

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7 January 2021

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

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7 January 2021

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

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7 January 2021

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

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7 January 2021

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

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7 January 2021

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

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7 January 2021

Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene.

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7 January 2021

Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans.

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7 January 2021

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

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7 January 2021

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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7 January 2021

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

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Direct control of the Forkhead transcription factor AFX by protein kinase B

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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7 January 2021

The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans.

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Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate

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Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span

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Aging and resistance to oxidative damage in Caenorhabditis elegans

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Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

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Regulation of lifespan by sensory perception in Caenorhabditis elegans

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Neurosecretory control of aging in Caenorhabditis elegans

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Signals from the reproductive system regulate the lifespan of C. elegans

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A delayed wave of death from reproduction in Drosophila.

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Extended life-span and stress resistance in the Drosophila mutant methuselah

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Elevated paraquat resistance can be used as a bioassay for longevity in a genetically based long-lived strain ofDrosophila

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Oxidative stress, caloric restriction, and aging

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7 January 2021

The p66shc adaptor protein controls oxidative stress response and life span in mammals

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A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.

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7 January 2021

The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans.

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7 January 2021

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.

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7 January 2021

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

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7 January 2021

FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies

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7 January 2021

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.

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clk-1, mitochondria, and physiological rates

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7 January 2021

Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span

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7 January 2021

The genetics of caloric restriction in Caenorhabditis elegans

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7 January 2021

Mutations in PROP1 cause familial combined pituitary hormone deficiency

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7 January 2021

Dwarf mice and the ageing process.

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7 January 2021

Does growth hormone prevent or accelerate aging?

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7 January 2021

Is the Laron mouse an accurate model of Laron syndrome?

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Low body temperature in long-lived Ames dwarf mice at rest and during stress.

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Catalase expression in delayed and premature aging mouse models

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Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase

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Regulation of C. elegans life-span by insulinlike signaling in the nervous system

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7 January 2021

Identifiers

DOI

10.1038/35041700

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

2838460

1003389377

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2838460

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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