A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling (Q28139198)

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scientific article (publication date: 26 March 1999)

Language	Label	Description	Also known as
English	A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling	scientific article (publication date: 26 March 1999)

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scholarly article

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A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling (English)

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author name string

L Wong

1

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T B Deb

2

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S A Thompson

3

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A Wells

4

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G R Johnson

5

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language of work or name

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publication date

26 March 1999

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Journal of Biological Chemistry

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274

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13

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8900-9

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Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

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Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene

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Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors

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Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

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Regulation of signal transduction and signal diversity by receptor oligomerization

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Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor

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Structure and function of human amphiregulin: a member of the epidermal growth factor family

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COOH-terminal extended recombinant amphiregulin with bioactivity comparable with naturally derived growth factor

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A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

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Betacellulin: a mitogen from pancreatic beta cell tumors

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Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate

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Heparin-dependent binding and autophosphorylation of epidermal growth factor (EGF) receptor by heparin-binding EGF-like growth factor but not by EGF.

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Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7

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A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin

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Amphiregulin-dependent proliferation of cultured human keratinocytes: autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans

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Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon

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Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells

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Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy.

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Expression of amphiregulin, a novel gene of the epidermal growth factor family, in human gastric carcinomas.

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Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas.

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Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells

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Epidermal growth factor receptor-dependent stimulation of amphiregulin expression in androgen-stimulated human prostate cancer cells

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Signal transduction by receptors with tyrosine kinase activity

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Ligand-induced transformation by a noninternalizing epidermal growth factor receptor

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Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis

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Involvement of ErbB2 in the signaling pathway leading to cell cycle progression from a truncated epidermal growth factor receptor lacking the C-terminal autophosphorylation sites

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Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation

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STAT activation by epidermal growth factor (EGF) and amphiregulin. Requirement for the EGF receptor kinase but not for tyrosine phosphorylation sites or JAK1.

1 reference

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Variants of 3T3 cells lacking mitogenic response to epidermal growth factor

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

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Transcriptional regulation by extracellular signals: mechanisms and specificity

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How receptor tyrosine kinases activate Ras.

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A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation.

1 reference

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Epidermal growth factor induces coupling of protein-tyrosine phosphatase 1D to GRB2 via the COOH-terminal SH3 domain of GRB2

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Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement

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Mitogenic signaling from the egf receptor is attenuated by a phospholipase C-gamma/protein kinase C feedback mechanism

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Tumor promoter and epidermal growth factor stimulate phosphorylation of the c-erbB-2 gene product in MKN-7 human adenocarcinoma cells

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Phosphorylation process induced by epidermal growth factor alters the oncogenic and cellular neu (NGL) gene products

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Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts

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Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

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An incomplete program of cellular tyrosine phosphorylations induced by kinase-defective epidermal growth factor receptors

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Transfer of functional EGF receptors to an IL3-dependent cell line

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Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains.

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes

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Localization of amphiregulin in the human placenta and decidua throughout gestation: role in trophoblast growth

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Prolactin inhibits epidermal growth factor-induced Ras-MAPK signaling in mammary epithelial cells

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Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells

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10.1074/JBC.274.13.8900

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