Human Pancreatic Islets Express mRNA Species Encoding Two Distinct Catalytically Active Isoforms of Group VI Phospholipase A2 (iPLA2) [etc.] (Q28139679)

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scientific article (publication date: 2 April 1999)

Language	Label	Description	Also known as
English	Human Pancreatic Islets Express mRNA Species Encoding Two Distinct Catalytically Active Isoforms of Group VI Phospholipase A2 (iPLA2) [etc.]	scientific article (publication date: 2 April 1999)

Statements

scholarly article

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Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1 (English)

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alternative mRNA splicing, via spliceosome

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human chromosome 22

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Phospholipase A1

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author name string

Z Ma

1

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X Wang

2

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W Nowatzke

3

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S Ramanadham

4

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J Turk

5

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language of work or name

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publication date

2 April 1999

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Journal of Biological Chemistry

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274

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9607-16

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14

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Phospholipases A2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

20 March 2017

Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity

1 reference

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20 March 2017

DNA sequencing with chain-terminating inhibitors

1 reference

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20 March 2017

Mads and Smads in TGF beta signalling

1 reference

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20 March 2017

Platelet-activating factor acetylhydrolases

1 reference

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20 March 2017

Characterization of functional domains within Smad4/DPC4

1 reference

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20 March 2017

A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs

1 reference

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20 March 2017

Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes

1 reference

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20 March 2017

Diversity of group types, regulation, and function of phospholipase A2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

20 March 2017

Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

20 March 2017

Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: prominence of plasmenylethanolamine molecular species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

20 March 2017

The Fas death factor

1 reference

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7 April 2017

Establishment and characterization of a human histiocytic lymphoma cell line (U-937)

1 reference

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7 April 2017

Cloning and expression of a group IV cytosolic Ca2+-dependent phospholipase A2 from rat pancreatic islets. Comparison of the expressed activity with that of an islet group VI cytosolic Ca2+-independent phospholipase A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

29 September 2017

Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism

1 reference

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29 September 2017

The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway

1 reference

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29 September 2017

Properties and regulation of cytosolic phospholipase A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

29 September 2017

DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells

1 reference

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29 September 2017

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

29 September 2017

Depletion of intracellular calcium stores activates smooth muscle cell calcium-independent phospholipase A2. A novel mechanism underlying arachidonic acid mobilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

29 September 2017

Cloning of human pancreatic islet large conductance Ca(2+)-activated K+ channel (hSlo) cDNAs: evidence for high levels of expression in pancreatic islets and identification of a flanking genetic marker

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

29 September 2017

Contenders in FasL/TNF death signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

29 September 2017

Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

29 September 2017

Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

29 September 2017

Ankyrins. Adaptors between diverse plasma membrane proteins and the cytoplasm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

29 September 2017

High-resolution mapping of mammalian genes by in situ hybridization to free chromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

29 September 2017

Alternative mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

29 September 2017

Allelic loss on chromosome 22 in oral cancer: possibility of the existence of a tumor suppressor gene on 22q13.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

SMADs: mediators and regulators of TGF-beta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Electrospray ionization mass spectrometric analyses of phospholipids from rat and human pancreatic islets and subcellular membranes: comparison to other tissues and implications for membrane fusion in insulin exocytosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Involvement of phosphatidate phosphohydrolase in arachidonic acid mobilization in human amnionic WISH cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Antisense inhibition of group VI Ca2+-independent phospholipase A2 blocks phospholipid fatty acid remodeling in murine P388D1 macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Caspase activity is required for commitment to Fas-mediated apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

A reassessment of the low molecular weight phospholipase A2 gene family in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Function and inhibition of intracellular calcium-independent phospholipase A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Identity between the Ca2+-independent phospholipase A2 enzymes from P388D1 macrophages and Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

The growing phospholipase A2 superfamily of signal transduction enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Bromoenol lactone inhibits magnesium-dependent phosphatidate phosphohydrolase and blocks triacylglycerol biosynthesis in mouse P388D1 macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Expression, purification, and kinetic characterization of a recombinant 80-kDa intracellular calcium-independent phospholipase A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Arachidonate mobilization is coupled to depletion of intracellular calcium stores and influx of extracellular calcium in differentiated U937 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Ca(2+)-independent cytosolic phospholipase A2 from macrophage-like P388D1 cells. Isolation and characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Concomitant acceleration of the activation and inactivation kinetics of the human delayed rectifier K+ channel (Kv1.1) by Ca(2+)-independent phospholipase A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

ATP-sensitive K channel modulation by products of PLA2 action in the insulin-secreting HIT cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Characterization by electrospray mass spectrometry of human Ca(2+)-sensitive cytosolic phospholipase A2 produced in baculovirus-infected insect cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

Automated method for isolation of human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715997

2 June 2018

TGF-beta signaling, Smads, and tumor suppressors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.14.9607

21 January 2018

Competitive PCR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.14.9607

21 January 2018

Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in beta-cell cytosolic calcium ion concentration

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modes of DAPI banding and simultaneous in situ hybridization

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of a new target region of allelic loss to a 2-cM interval at 22q13.1 in primary breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The specific association of a phosphofructokinase isoform with myocardial calcium-independent phospholipase A2. Implications for the coordinated regulation of phospholipolysis and glycolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: a possible molecular component of the beta-cell fuel sensor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the expression of cytosolic calcium-independent phospholipase A2 (88kDa) in immature and mature myeloid cells and its role in leukotriene synthesis in human granulocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas-induced arachidonic acid release is mediated by Ca2+-independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mass spectrometric evidence that agents that cause loss of Ca2+ from intracellular compartments induce hydrolysis of arachidonic acid from pancreatic islet membrane phospholipids by a mechanism that does not require a rise in cytosolic Ca2+ concentr

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for association of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from pancreatic islets and HIT insulinoma cells with a phosphofructokinase-like protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The calcium-dependent association and functional coupling of calmodulin with myocardial phospholipase A2. Implications for cardiac cycle-dependent alterations in phospholipolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10092647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.274.14.9607

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