Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain (Q28141275)

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scientific article (publication date: 13 October 2000)

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English	Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain	scientific article (publication date: 13 October 2000)

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scholarly article

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Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain (English)

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author name string

T O'Donnell

1

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S Rotzinger

2

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T T Nakashima

3

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C C Hanstock

4

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M Ulrich

5

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P H Silverstone

6

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language of work or name

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publication date

13 October 2000

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880

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1-2

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84-91

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Reduced Brain Inositol in Lithium-treated Rats

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The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS

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Increase in AP-1 transcription factor DNA binding activity by valproic acid.

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The antibipolar drug valproate mimics lithium in stimulating glutamate release and inositol 1,4,5-trisphosphate accumulation in brain cortex slices but not accumulation of inositol monophosphates and bisphosphates

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Chronic lithium administration alters a prominent PKC substrate in rat hippocampus

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10.1016/S0006-8993(00)02797-9

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