Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP) (Q28142482)

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A J Fosang

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K Last

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F A Mercuri

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A M Pendás

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E Llano

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R Perris

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P E Di Cesare

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G Murphy

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V Knäuper

Matrix metalloproteinases

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language of work or name

English

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publication date

28 July 2000

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published in

FEBS Letters

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volume

478

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issue

1-2

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page(s)

52-6

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Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

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Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

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Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain

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Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

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VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis

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Aggrecan degradation in human intervertebral disc and articular cartilage

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Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

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Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

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Increased serum concentrations of cartilage oligomeric matrix protein. A prognostic marker in early rheumatoid arthritis

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Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids

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Interleukin-1 and oncostatin M in combination promote the release of collagen fragments from bovine nasal cartilage in culture

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Inhibition of cartilage degradation and changes in physical properties induced by IL-1beta and retinoic acid using matrix metalloproteinase inhibitors

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Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity

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Small fragments of cartilage oligomeric matrix protein in synovial fluid and serum as markers for cartilage degradation

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Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: The Johnston county osteoarthritis project

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inferred from DOI database lookup

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based on heuristic

Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood

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Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint

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Inhibition of interleukin-1alpha-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibitors: potential role for matrix metalloproteinases in the generation of cartilage oligomeric mat

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Matrix metalloproteinase inhibitor CGS 27023A protects COMP and proteoglycan in the bovine articular cartilage but not the release of their fragments from cartilage after prolonged stimulation in vitro with IL-1 alpha

7 January 2021

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Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase

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Electrophoresis of 35S-labeled proteoglycans on polyacrylamide-agarose composite gels and their visualization by fluorography

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Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

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