NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms (Q28142533)

Europe PubMed Central

title

NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms (English)

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author name string

D Ross

1

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J K Kepa

2

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S L Winski

3

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H D Beall

4

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A Anwar

5

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D Siegel

Chemico-biological Interactions

6

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language of work or name

English

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publication date

1 December 2000

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published in

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volume

129

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issue

1-2

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page(s)

77-97

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Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity.

7 January 2021

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Effect of inducers of DT-diaphorase on the toxicity of 2-methyl- and 2-hydroxy-1,4-naphthoquinone to rats

7 January 2021

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NAD(P)H:quinone oxidoreductase1 (DT diaphorase) specifically prevents the formation of benzo[a]pyrene quinone-DNA adducts generated by cytochrome P4501A1 and P450 reductase

7 January 2021

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Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma

7 January 2021

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Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells

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A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity

7 January 2021

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The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems

7 January 2021

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DT-Diaphorase maintains the reduced state of ubiquinones in lipid vesicles thereby promoting their antioxidant function

7 January 2021

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Reduction of alpha-tocopherolquinone to alpha-tocopherolhydroquinone in rat hepatocytes

7 January 2021

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7 January 2021

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The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant

7 January 2021

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Redox cycles of vitamin E: hydrolysis and ascorbic acid dependent reduction of 8a-(alkyldioxy)tocopherones

7 January 2021

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Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol

7 January 2021

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Conversion of 4-nitroquinoline 1-oxide (4NQO) to 4-hydroxyaminoquinoline 1-oxide by a dicumarol-resistant hepatic 4NQO nitroreductase in rats and mice.

7 January 2021

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Purified NAD(P)H-quinone oxidoreductase enhances the mutagenicity of dinitropyrenes in vitro

7 January 2021

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Mechanisms of action of quinone-containing alkylating agents. I: NQO1-directed drug development

7 January 2021

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Gene targeting of DT-diaphorase in mouse embryonic stem cells: establishment of null mutant and its mitomycin C-resistance.

7 January 2021

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Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents

7 January 2021

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Indolequinone antitumor agents: Relationship between quinone structure and rate of metabolism by recombinant human NQO1

7 January 2021

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7 January 2021

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The case for mitomycin in non-small cell lung cancer

7 January 2021

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Bioreductive activation of mitomycin C by DT-diaphorase

7 January 2021

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Indolequinone Antitumor Agents: Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro Cytotoxicity1

7 January 2021

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Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development

7 January 2021

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Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

7 January 2021

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Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase

7 January 2021

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Cyclopropamitosenes, Novel Bioreductive Anticancer Agents. Synthesis, Electrochemistry, and Biological Activity of 7-Substituted Cyclopropamitosenes and Related Indolequinones

7 January 2021

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2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo

7 January 2021

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Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymatic reduction by DT-diaphorase

7 January 2021

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Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice

7 January 2021

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Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity

7 January 2021

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Evidence for DNA phosphate backbone alkylation and cleavage by pyrrolo[1,2-a]benzimidazoles: small molecules capable of causing base-pair-specific phosphodiester bond hydrolysis

7 January 2021

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Studies of pyrrolo[1,2-alpha]benzimidazolequinone DT-diaphorase substrate activity, topoisomerase II inhibition activity, and DNA reductive alkylation

7 January 2021

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Design of highly active analogues of the pyrrolo[1,2-a]benzimidazole antitumor agents.

7 January 2021

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Novel quinolinequinone antitumor agents: Structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1)

7 January 2021

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Mechanisms of benzene carcinogenesis: application of a physiological model of benzene pharmacokinetics and metabolism

7 January 2021

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2,4-dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256.

7 January 2021

1 reference

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A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

7 January 2021

1 reference

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Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs

7 January 2021

1 reference

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Glutathione S-transferase pi facilitates the excretion of arsenic from arsenic-resistant Chinese hamster ovary cells

7 January 2021

1 reference

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DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

7 January 2021

1 reference

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Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin

7 January 2021

1 reference

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A refined physical map of the long arm of human chromosome 16

7 January 2021

1 reference

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Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion

7 January 2021

1 reference

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The role of specific reductases in the intracellular activation and binding of 2-nitroimidazoles

7 January 2021

1 reference

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Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity

7 January 2021

1 reference

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Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

7 January 2021

1 reference

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Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Human antioxidant-response-element-mediated regulation of type 1 NAD(P)H:quinone oxidoreductase gene expression. Effect of sulfhydryl modifying agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Antioxidant response element

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Chemical and molecular regulation of enzymes that detoxify carcinogens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

p38 mitogen-activated protein kinase negatively regulates the induction of phase II drug-metabolizing enzymes that detoxify carcinogens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Regulation of c-jun expression during hypoxic and low-glucose stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-kappa B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

The redox-sensitive human antioxidant responsive element induces gene expression under low oxygen conditions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Functional antioxidant responsive elements.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Activation of antioxidant/electrophile-responsive elements in IMR-32 human neuroblastoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

DT-diaphorase activity in NSCLC and SCLC cell lines: a role for fos/jun regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Disruption of c-Fos leads to increased expression of NAD(P)H:quinone oxidoreductase1 and glutathione S-transferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Transcriptional regulation of the human quinone reductase gene by antiestrogen-liganded estrogen receptor-alpha and estrogen receptor-beta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Detection of a nuclear protein which binds specifically to the antioxidant responsive element (ARE) of the human NAD(P) H:quinone oxidoreductase gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

The Ah receptor and the mechanism of dioxin toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Role of cytochrome P1-450 in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Antioxidant response element-mediated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induction of human NAD(P)H:quinone oxidoreductase 1 gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Transfection of COS-1 cells with DT-diaphorase cDNA: role of a base change at position 609

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

inferred from DOI database lookup

7 January 2021

based on heuristic

Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

609 C --> T polymorphism in NAD(P)H:quinone oxidoreductase gene in patients with prostatic adenocarcinoma or benign prostatic hyperplasia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X

Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900199-X