TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes (Q28142929)

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W G van Eyndhoven

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E Schweiger

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M Mossbacher

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B Koo

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S Lederman

4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB

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language of work or name

English

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publication date

2000

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37

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issue

1-2

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page(s)

73-84

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cites work

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Expression of constitutively active IkappaB beta in T cells of transgenic mice: persistent NF-kappaB activity is required for T-cell immune responses

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NF-kappa B: ten years after

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Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily

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TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.

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Involvement of CRAF1, a relative of TRAF, in CD40 signaling

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Separate binding sites on nuclear transport factor 2 (NTF2) for GDP-Ran and the phenylalanine-rich repeat regions of nucleoporins p62 and Nsp1p

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An intact zinc ring finger is required for tumor necrosis factor receptor-associated factor-mediated nuclear factor-kappaB activation but is dispensable for c-Jun N-terminal kinase signaling

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Identification and characterization of a nuclear pore complex protein

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

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A complex of nuclear pore proteins required for pore function

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Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor

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CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins

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Distinct functions for the two importin subunits in nuclear protein import

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B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells

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Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

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ASK1 is essential for JNK/SAPK activation by TRAF2

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Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62

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Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import

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High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization

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CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization

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Identification and characterization of an IkappaB kinase

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Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

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TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

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I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction

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A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40

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Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1

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Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

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Primary sequence and heterologous expression of nuclear pore glycoprotein p62

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TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activation

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Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB

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MultiCoil: a program for predicting two- and three-stranded coiled coils

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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

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Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.

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The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

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