Inhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs) (Q28144746)

2

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A Ullrich

3

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M I Greene

4

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D M O'Rourke

Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

5

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language of work or name

English

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publication date

17 August 2000

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published in

Oncogene

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volume

19

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issue

35

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page(s)

3999-4010

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cites work

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Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

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Inhibitory receptors abound?

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Geometric control of cell life and death

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Negative signaling in health and disease.

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Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.

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A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation.

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A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion

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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

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A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes

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Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

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Cell adhesion: the molecular basis of tissue architecture and morphogenesis

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Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

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Integrin-associated protein is a ligand for the P84 neural adhesion molecule

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A family of proteins that inhibit signalling through tyrosine kinase receptors

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility

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Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor

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Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

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Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: implications for subdomain contributions to receptor assembly.

21 January 2018

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Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells

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Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains.

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Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.

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Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule

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SHP-2 is involved in neurotrophin signaling

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Variants of 3T3 cells lacking mitogenic response to epidermal growth factor

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Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals

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Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells

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Regulation of Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the epidermal growth factor receptor

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Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

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The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases

21 January 2018

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Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation

21 January 2018

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

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Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases

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High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages

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Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction

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PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.

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Sustained mitogen-activated protein kinase activation is induced by transforming erbB receptor complexes

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

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Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons

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Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes

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Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

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Epidermal growth factor-induced association of the SHPTP2 protein tyrosine phosphatase with a 115-kDa phosphotyrosine protein

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Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion

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p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells

21 January 2018

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The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation

21 January 2018

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Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs

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Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and phosphatidylinositol 3'-kinase in myeloid cells

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7 January 2021

Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and phosphatidylinositol 3-kinase with a 100-kDa tyrosine-phosphorylated protein in hemopoietic cells

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7 January 2021

Roles for the protein tyrosine phosphatase SHP-2 in cytoskeletal organization, cell adhesion and cell migration revealed by overexpression of a dominant negative mutant

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7 January 2021

Epidermal growth factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2, a SH2 domain-containing protein tyrosine phosphatase

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7 January 2021

Domain-specific Interactions between the p185neuand Epidermal Growth Factor Receptor Kinases Determine Differential Signaling Outcomes

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7 January 2021

Formation of distinct signalling complexes involving phosphatidylinositol 3-kinase activity with stimulation of epidermal growth factor or insulin-like growth factor-I in human skin fibroblasts

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7 January 2021

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development

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7 January 2021

Regulation of neuregulin-mediated acetylcholine receptor synthesis by protein tyrosine phosphatase SHP2.

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7 January 2021