Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63 (Q28180800)

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Andree Blaukat

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Ali Ardati

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Evi Kostenis

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

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language of work or name

English

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publication date

April 2003

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published in

Cellular Signalling

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volume

15

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issue

4

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page(s)

435-46

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cites work

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Lysophosphatidic acid is a chemoattractant for Dictyostelium discoideum amoebae.

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Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

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Lysophosphatidic acid increases tight junction permeability in cultured brain endothelial cells.

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The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho.

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Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes.

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Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems

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7 January 2021

Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid

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Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors

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Potentiation of GPCR-signaling via membrane targeting of G protein alpha subunits

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Chimeric green fluorescent protein-aequorin as bioluminescent Ca2+ reporters at the single-cell level

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Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha

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Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells

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A fluorescent reporter assay for the detection of ligands acting through Gi protein-coupled receptors

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Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay

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Functional characterization of a human receptor for neuropeptide FF and related peptides

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Adaptation of aequorin functional assay to high throughput screening

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Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5

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Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis

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Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

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Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors

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7 January 2021

Identification of four novel human G protein-coupled receptors expressed in the brain

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Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration

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7 January 2021

Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45

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7 January 2021

Lysophospholipid receptors

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Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum

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Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility

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An anorexic lipid mediator regulated by feeding.

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Isolation and structure of a brain constituent that binds to the cannabinoid receptor

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Phosphatidic acid modulates G protein regulation of phospholipase C-beta1 activity in membranes

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7 January 2021

Sphingosine 1-phosphate signaling: providing cells with a sense of direction

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Pharmacological importance of phospholipase D and phosphatidic acid in the regulation of the mitogen-activated protein kinase cascade

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7 January 2021

Two novel Xenopus homologs of mammalian LP(A1)/EDG-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells

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A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors

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Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.

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