DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses (Q28182624)

2

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Heather M Craig

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Michael H Malim

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Michael S Neuberger

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

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language of work or name

English

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publication date

July 2003

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published in

Nature Immunology

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volume

4

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issue

7

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page(s)

641-3

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cites work

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The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

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DNA deamination mediates innate immunity to retroviral infection

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Hypermutation of HIV-1 DNA in the Absence of the Vif Protein

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Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

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RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

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An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22

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C-to-U RNA editing: mechanisms leading to genetic diversity

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

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The regulation of primate immunodeficiency virus infectivity by Vif is cell species restricted: a role for Vif in determining virus host range and cross-species transmission

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A new type of G-->A hypermutation affecting human immunodeficiency virus

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Sustained G-->A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome

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Human immunodeficiency virus type 1 DNA sequences genetically damaged by hypermutation are often abundant in patient peripheral blood mononuclear cells and may be generated during near-simultaneous infection and activation of CD4(+) T cells

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1)

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AID mediates hypermutation by deaminating single stranded DNA.

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Quality control by DNA repair

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Incorporation of uracil into minus strand DNA affects the specificity of plus strand synthesis initiation during lentiviral reverse transcription

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Naturally occurring hepatitis B virus genomes bearing the hallmarks of retroviral G-->A hypermutation

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Selection, recombination, and G----A hypermutation of human immunodeficiency virus type 1 genomes

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Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: identification of replication-competent and -defective viral genomes

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A highly defective HIV-1 group O provirus: evidence for the role of local sequence determinants in G-->A hypermutation during negative-strand viral DNA synthesis

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Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes

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7 January 2021