Alzheimer's disease: the cholesterol connection (Q28186482)

https://scigraph.springernature.com/pub.10.1038/nn0403-345

Europe PubMed Central

title

Alzheimer's disease: the cholesterol connection (English)

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Rudolph E Tanzi

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author name string

Luigi Puglielli

series ordinal

1

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Dora M Kovacs

series ordinal

3

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language of work or name

English

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publication date

April 2003

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published in

Nature Neuroscience

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volume

6

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page(s)

345-51

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issue

4

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exact match

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cites work

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

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Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.

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Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner

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A protective role of the low density lipoprotein receptor-related protein against amyloid beta-protein toxicity

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Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells.

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Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

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Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

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Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy

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Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.

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Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

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Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice

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Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

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7 January 2021

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

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7 January 2021

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol.

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7 January 2021

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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7 January 2021

The Alzheimer amyloid precursor is associated with the detergent- insoluble cytoskeleton

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7 January 2021

A detergent-insoluble membrane compartment contains A beta in vivo.

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7 January 2021

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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7 January 2021

The interaction between Alzheimer amyloid beta(1-40) peptide and ganglioside GM1-containing membranes

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7 January 2021

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7 January 2021

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7 January 2021

The role of cholesterol in the biosynthesis of beta-amyloid

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7 January 2021

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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7 January 2021

Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content

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7 January 2021

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

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https://api.crossref.org/works/10.1038%2FNN0403-345

7 January 2021

Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

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7 January 2021

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

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7 January 2021

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

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7 January 2021

Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2

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https://api.crossref.org/works/10.1038%2FNN0403-345

7 January 2021

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1 reference

https://api.crossref.org/works/10.1038%2FNN0403-345

7 January 2021

The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing

1 reference

https://api.crossref.org/works/10.1038%2FNN0403-345

7 January 2021

Cholesterol metabolism in the brain

1 reference

https://api.crossref.org/works/10.1038%2FNN0403-345

7 January 2021

Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.

1 reference

https://api.crossref.org/works/10.1038%2FNN0403-345

7 January 2021

Is there a connection between the concentration of cholesterol circulating in plasma and the rate of neuritic plaque formation in Alzheimer disease?

1 reference

https://api.crossref.org/works/10.1038%2FNN0403-345

7 January 2021

The metabolism of cholestanol, cholesterol, and bile acids in cerebrotendinous xanthomatosis

1 reference

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7 January 2021

Increased concentrations of cholestanol and apolipoprotein B in the cerebrospinal fluid of patients with cerebrotendinous xanthomatosis. Effect of chenodeoxycholic acid

1 reference

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7 January 2021