Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4 (Q28189949)

Europe PubMed Central

title

Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4 (English)

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author name string

C A Blanchong

1

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E K Chung

2

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K L Rupert

3

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Y Yang

4

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Z Yang

5

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B Zhou

6

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J M Moulds

7

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C Y Yu

International Immunopharmacology

8

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language of work or name

English

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publication date

March 2001

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published in

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volume

1

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issue

3

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page(s)

365-92

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cites work

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A comparison of the properties of two classes, C4A and C4B, of the human complement component C4

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7 January 2021

The reaction mechanism of the internal thioester in the human complement component C4.

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The role of complement and its receptor in the elimination of immune complexes

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Primate erythrocyte-immune complex-clearing mechanism

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7 January 2021

The binding of human complement component C4 to antibody-antigen aggregates

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7 January 2021

The fluid-phase binding of human C4 and its genetic variants, C4A3 and C4B1, to immunoglobulins

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7 January 2021

Complement-mediated adherence of immune complexes to human erythrocytes. Difference in the requirements for C4A and C4B

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7 January 2021

C4-mediated inhibition of immune precipitation and differences in inhibitory action of genetic variants, C4A3 and C4B1

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7 January 2021

Differences between C4A and C4B in the handling of immune complexes: the enhancement of CR1 binding is more important than the inhibition of immunoprecipitation

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7 January 2021

Inherited structural polymorphism of the fourth component of human complement

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7 January 2021

Localisation of Chido and Rodgers determinants to the C4d fragment of human C4

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7 January 2021

Antigenic determinants expressed by human C4 allotypes; a study of 325 families provides evidence for the structural antigenic model

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7 January 2021

A structural model for the location of the Rodgers and the Chido antigenic determinants and their correlation with the human complement component C4A/C4B isotypes

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https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

DNA sequence analysis of the C4 antigen WH: evidence for two mechanisms of expression

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Reference typing report for complement component C4.

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7 January 2021

Definitive RFLPs to distinguish between the human complement C4A/C4B isotypes and the major Rodgers/Chido determinants: application to the study of C4 null alleles

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https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Polymorphism of the human complement C4 and steroid 21-hydroxylase genes. Restriction fragment length polymorphisms revealing structural deletions, homoduplications, and size variants

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https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Relationship between protein complotypes and DNA variant haplotypes: complotype-RFLP constellations (CRC)

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https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Polymorphism of human complement component C4.

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https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Molecular genetics of the human MHC complement gene cluster

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The human and mouse MHC class III region: a parade of 21 genes at the centromeric segment

1 reference

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7 January 2021

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B

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https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Modular variations of the human major histocompatibility complex class III genes for serine/threonine kinase RP, complement component C4, steroid 21-hydroxylase CYP21, and tenascin TNX (the RCCX module). A mechanism for gene deletions and disease as

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Deficiencies of human complement component C4A and C4B and heterozygosity in length variants of RP-C4-CYP21-TNX (RCCX) modules in caucasians. The load of RCCX genetic diversity on major histocompatibility complex-associated disease

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Two HLA-linked loci controlling the fourth component of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Chido and Rodgers blood groups are distinct antigenic components of human complement C4.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Genetic polymorphism of human complement C4 and detection of heterozygotes

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Genetics of human C4 polymorphism: detection and segregation of rare and duplicated haplotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Gene organization of haplotypes expressing two different C4A allotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The study of a French family with two duplicated C4A haplotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Polymorphism of MHC class III genes: definition of restriction fragment linkage groups and evidence for frequent deletions and duplications

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https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The genomic structure of two ancestral haplotypes carrying C4A duplications

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7 January 2021

A molecular basis for the two locus model of human complement component C4

1 reference

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7 January 2021

Organization of the chimpanzee C4-CYP21 region: implications for the evolution of human genes

1 reference

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7 January 2021

Major histocompatibility complex (MHC) class III genetics in two Amerindian tribes from southern Brazil: the Kaingang and the Guarani

1 reference

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7 January 2021

Common evolutionary origin of alpha 2-macroglobulin and complement components C3 and C4.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Molecular evolution of the vertebrate immune system

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7 January 2021

Molecular analysis of the human and mouse alpha 2M family

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7 January 2021

Primary structure of pregnancy zone protein. Molecular cloning of a full-length PZP cDNA clone by the polymerase chain reaction

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7 January 2021

Biochemistry and biology of anaphylatoxins

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7 January 2021

Comparative structural anatomy of the complement anaphylatoxin proteins C3a, C4a and C5a

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https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Distal recognition site for classical pathway convertase located in the C345C/netrin module of complement component C5.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

A single chain precursor of C4 in human serum

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Fourth component of human complement: description of a three polypeptide chain structure

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Cell-free synthesis of the fourth component of guinea pig complement (C4): identification of a precursor of serum C4 (pro-C4)

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Precursor complement protein (pro-C4) is converted in vitro to native C4 by plasmin

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Detection of disulphide bonds and localization of interchain linkages in the third (C3) and the fourth (C4) components of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Covalent binding and hemolytic activity of complement proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Fourth component of human complement: studies of an amine-sensitive site comprised of a thiol component.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Sequence determination of the thiolester site of the fourth component of human complement.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Intramolecular general acid catalysis in the binding reactions of alpha 2-macroglobulin and complement components C3 and C4

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Tyrosine sulfation: a modulator of extracellular protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Sulfation of tyrosine residues increases activity of the fourth component of complement

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The isolation and structure of C4, the fourth component of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The structural basis of the multiple forms of human complement component C4.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Characterization of the Mr difference between secreted murine fourth component of complement and the major plasma form: evidence for carboxyl-terminal cleavage of the alpha chain

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Amino acid sequence homologies and glycosylation differences between the fourth component of murine complement and sex-limited protein

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The C4 and Slp genes of the complement region of the murine H-2 major histocompatibility complex

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Complete cDNA sequence of the fourth component of murine complement

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Identification and structural characterization of two incompletely processed forms of the fourth component of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The primary structure of the fourth component of human complement (C4)-C-terminal peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Phenotyping of human complement component C4, a class-III HLA antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The chemical structure of the C4d fragment of the human complement component C4.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Human complement component C4. Structural studies on the fragments derived from C4b by cleavage with C3b inactivator

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Primary sequence differences between Chido and Rodgers variants of tryptic C4d of the human complement system

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Cloning of a human complement component C4 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

New DNA sequences for the human complement gene C4.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The purification and properties of some less common allotypes of the fourth component of human complement

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

C4 genes of the chimpanzee, gorilla, and orang-utan: evidence for extensive homogenization.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

C4 gene polymorphism in primates: evolution, generation, and Chido and Rodgers antigenicity

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The thioester and isotypic sites of complement component C4 in sheep and cattle.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The phylogeny and evolution of the thioester bond-containing proteins C3, C4 and alpha 2-macroglobulin.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Origin of the fourth component of complement related Chido and Rodgers blood group antigens

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

A new antigenic determinant for C4 of relatively low frequency

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Different HLA antigen associations for the functionally active and inactive products of the complement C4F1 allele

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The low C5 convertase activity of the C4A6 allotype of human complement component C4.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

A mechanism of activation of the alternative complement pathway by the classical pathway: protection of C3b from inactivation by covalent attachment to C4b.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Mouse complement component C4 is devoid of classical pathway C5 convertase subunit activity

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Allotypes of the fourth component of complement in Korean

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Complement C4A, C4B and BF haplotypes in Koreans

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The C4 beta-chain: evidence for a genetically determined polymorphism

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

An estimate on the frequency of duplicated haplotypes and silent alleles of human C4 protein polymorphism. I. Investigations in healthy Caucasoid families

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

An epitope on C4 beta light (L) chains detected by human anti-Rg; its relationship with beta chain polymorphism and MHC associations

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Characterization of two hybrid C4 allotypes (C4A*12andC4B*3) by electrophoretic, serological and restriction fragment length polymorphism analyses

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

S region genetic control of murine C4 biosynthesis: analysis of pro-C4 cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Some new antigens and histocompatibility factors in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The murine H-2.7 specificity is an antigenic determinant of C4d, a fragment of the fourth component of the complement system

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Transcriptional regulation of complement genes

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Drawing a double-edged sword

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Biosynthesis of complement C4 messenger RNA in normal human kidney

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Counterregulatory effects of interferon-gamma and endotoxin on expression of the human C4 genes

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Cellular localization of complement C3 and C4 transcripts in intestinal specimens from patients with Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Differential expression of complement C3 and C4 in the human kidney

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Cytokine-regulated production of the major histocompatibility complex class-III-encoded complement proteins factor B and C4 by human glomerular mesangial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Interferon-gamma regulation of C4 gene expression in cultured human glomerular epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Complement biosynthesis by the human hepatoma-derived cell line HepG2

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Quantitative variation of C4 variant proteins associated with many MHC haplotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

H-2 S region determined polymorphic variants of the C4, Slp, C2, and B complement proteins: A compilation

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Genetic and structural characterization of H-2-controlled allelic forms of murine C4.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Insertion of the B2 sequence into intron 13 is the only defect of the H-2k C4 gene which causes low C4 production

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Gene-specific probes demonstrate selective duplications of the C4-Slp gene in the H-2S alleles associated with a testosterone-independent expression of this isotype

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Organizations and gene duplications of the human and mouse MHC complement gene clusters

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The role of Sp family members, basic Kruppel-like factor, and E box factors in the basal and IFN-gamma regulated expression of the human complement C4 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Null alleles of human complement C4. Evidence for pseudogenes at the C4A locus and for gene conversion at the C4B locus

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Characterization of non-expressed C4 genes in a case of complete C4 deficiency: identification of a novel point mutation leading to a premature stop codon

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Major histocompatibility complex haplotypes and complement C4 alleles in systemic lupus erythematosus. Results of a multicenter study

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

The 20 faces of the fourth component of complement

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Two clusters of acidic amino acids near the NH2 terminus of complement component C4 alpha'-chain are important for C2 binding

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Slp is an essential component of an EDTA-resistant activation pathway of mouse complement

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Sex-limited protein: in vitro and in vivo functions

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

A critical role for complement in maintenance of self-tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

Restriction fragment length polymorphisms of the complement component C4 loci on chromosome 6: studies with emphasis on the determination of gene number

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021

IFN-gamma mediates stimulation of complement C4 biosynthesis in human proximal tubular epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900019-4

7 January 2021