5-lipoxygenase and FLAP (Q28191619)

Europe PubMed Central

title

5-lipoxygenase and FLAP (English)

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author name string

M Peters-Golden

series ordinal

1

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T G Brock

series ordinal

2

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language of work or name

English

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publication date

2003

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Prostaglandins, Leukotrienes and Essential Fatty Acids

PubMed

published in

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volume

69

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issue

2-3

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page(s)

99-109

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cites work

On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors

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7 January 2021

Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase

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7 January 2021

Investigation of the mechanism of non-turnover-dependent inactivation of purified human 5-lipoxygenase. Inactivation by H2O2 and inhibition by metal ions

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7 January 2021

Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: binding characteristics and amino acid sequences

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7 January 2021

Physiochemical characterization of ATP binding to human 5-lipoxygenase.

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7 January 2021

Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils.

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7 January 2021

Regulation of eicosanoid biosynthesis in the macrophage. Involvement of protein tyrosine phosphorylation and modulation by selective protein tyrosine kinase inhibitors.

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7 January 2021

Inhibition of mitogen-activated protein kinase kinase blocks activation and redistribution of 5-lipoxygenase in HL-60 cells.

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7 January 2021

Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase

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7 January 2021

5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases

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7 January 2021

Endogenous nitric oxide inhibits leukotriene B4 release from rat alveolar macrophages

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7 January 2021

Prolonged exposure to lipopolysaccharide inhibits macrophage 5-lipoxygenase metabolism via induction of nitric oxide synthesis

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7 January 2021

The three-dimensional structure of an arachidonic acid 15-lipoxygenase

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7 January 2021

Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution

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7 January 2021

Structural and thermochemical characterization of lipoxygenase-catechol complexes

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7 January 2021

The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

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7 January 2021

Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

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7 January 2021

Structural characterization of the catalytic domain of the human 5-lipoxygenase enzyme

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7 January 2021

Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

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7 January 2021

The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity

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7 January 2021

The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation

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7 January 2021

Microsomal metabolism of the 5-lipoxygenase inhibitor L-739,010: evidence for furan bioactivation

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7 January 2021

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

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7 January 2021

Identification and isolation of a membrane protein necessary for leukotriene production

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7 January 2021

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

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7 January 2021

5-lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase

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7 January 2021

Increases in 5-lipoxygenase activating protein expression account for enhanced capacity for 5-lipoxygenase metabolism that accompanies differentiation of peripheral blood monocytes into alveolar macrophages

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7 January 2021

Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells

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7 January 2021

5-lipoxygenase-activating protein is an arachidonate binding protein

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Structural requirements for the binding of fatty acids to 5-lipoxygenase-activating protein

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7 January 2021

Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily

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7 January 2021

Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4

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7 January 2021

Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody

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7 January 2021

Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis

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7 January 2021

Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits

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7 January 2021

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7 January 2021

Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation.

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7 January 2021

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes

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7 January 2021

5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen

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7 January 2021

Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Translocation of cytosolic phospholipase A2 to the nuclear envelope elicits topographically localized phospholipid hydrolysis

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7 January 2021

Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages

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7 January 2021

Colocalization of cytosolic phospholipase A2, 5-lipoxygenase, and 5-lipoxygenase-activating protein at the nuclear membrane of A23187-stimulated human neutrophils.

1 reference

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7 January 2021

Membrane localization and topology of leukotriene C4 synthase

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Mechanisms of the priming effect of lipopolysaccharides on the biosynthesis of leukotriene B4 in chemotactic peptide-stimulated human neutrophils.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Rac and p38 kinase mediate 5-lipoxygenase translocation and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7

1 reference

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7 January 2021

Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Complexes of sequential metabolic enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Determinants of 5-lipoxygenase nuclear localization using green fluorescent protein/5-lipoxygenase fusion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Identification of a bipartite nuclear localization sequence necessary for nuclear import of 5-lipoxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Structural and functional criteria reveal a new nuclear import sequence on the 5-lipoxygenase protein

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Nuclear-localization-signal-dependent and nuclear-export-signal-dependent mechanisms determine the localization of 5-lipoxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

The PPARalpha-leukotriene B4 pathway to inflammation control.

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7 January 2021

Covalent binding of LTA(4) to nucleosides and nucleotides

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7 January 2021

Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Regulation of 5-lipoxygenase activity in mononuclear phagocytes: characterization of an endogenous cytosolic inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Co-localization of leukotriene a4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Amplification of LTB4 generation in AM-PMN cocultures: transcellular 5-lipoxygenase metabolism

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Interaction of 5-lipoxygenase with cellular proteins

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Transforming growth factor beta upregulates 5-lipoxygenase activity during myeloid cell maturation

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7 January 2021

Alveolar lining fluid regulates mononuclear phagocyte 5-lipoxygenase metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Contrasting effects of proinflammatory and T-helper lymphocyte subset-2 cytokines on the 5-lipoxygenase pathway in monocytes

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

c-kit ligand mediates increased expression of cytosolic phospholipase A2, prostaglandin endoperoxide synthase-1, and hematopoietic prostaglandin D2 synthase and increased IgE-dependent prostaglandin D2 generation in immature mouse mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Calcitriol and transforming growth factor-beta upregulate 5-lipoxygenase mRNA expression by increasing gene transcription and mRNA maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Granulocyte/macrophage colony-stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Granulocyte colony-stimulating factor administration to HIV-infected subjects augments reduced leukotriene synthesis and anticryptococcal activity in neutrophils

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Oxidized low density lipoprotein increases U937 cell 5-lipoxygenase activity: induction of 5-lipoxygenase activating protein

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Dexamethasone increases expression of 5-lipoxygenase and its activating protein in human monocytes and THP-1 cells

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

5-Lipoxygenase upregulation by dexamethasone in human mast cells

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Glucocorticoid receptors are required for up-regulation of neuronal 5-lipoxygenase (5LOX) expression by dexamethasone.

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7 January 2021

Reduced 5-lipoxygenase metabolism of arachidonic acid in macrophages rrom 1,25-dihydroxyvitamin D3-deficient rats

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Regulation of 5-lipoxygenase metabolism in mononuclear phagocytes by CD4 T lymphocytes

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https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

Characterization of the human 5-lipoxygenase gene promoter

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7 January 2021

Cloning and functional analysis of the mouse 5-lipoxygenase promoter

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7 January 2021

Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants

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7 January 2021

Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription

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7 January 2021

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

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7 January 2021

Novel polymorphism of the 5-lipoxygenase activating protein (FLAP) promoter gene associated with asthma

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7 January 2021

10.1016/S0952-3278(03)00070-X

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

3680286

3680286

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference