Angiotensin II receptor type 1 (Q2819188)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30556

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.13.1

hierarchical database ID heuristic

2 October 2019

based on heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

angiotensin type II receptor activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

Cloning and characterization of a human angiotensin II type 1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

angiotensin type I receptor activity

signal transducer activity

IPI

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30556&geneProductId=UniProtKB:P30556

bradykinin receptor binding

IEA

1 reference

8 April 2019

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

6 references

8 April 2019

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

protein heterodimerization activity

IPI

1 reference

8 April 2019

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

angiotensin type I receptor activity

IPI

3 references

8 April 2019

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

G protein-coupled receptor activity

IBA

integral component of membrane

3 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30556&geneProductId=UniProtKB:P30556

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30556&geneProductId=UniProtKB:P30556

10 September 2018

Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30556&geneProductId=UniProtKB:P30556

integral component of plasma membrane

1 reference

8 April 2019

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

intracellular anatomical structure

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30556&geneProductId=UniProtKB:P30556

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

positive regulation of protein metabolic process

IBA

biological process

1 reference

8 April 2019

Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

1 reference

8 April 2019

Cloning and characterization of a human angiotensin II type 1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

positive regulation of inflammatory response

1 reference

8 April 2019

Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

maintenance of blood vessel diameter homeostasis by renin-angiotensin

1 reference

8 April 2019

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

positive regulation of phospholipase A2 activity

1 reference

8 April 2019

Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

regulation of renal sodium excretion

1 reference

8 April 2019

Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

1 reference

8 April 2019

Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

positive regulation of cholesterol esterification

1 reference

8 April 2019

Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

phospholipase C-activating angiotensin-activated signaling pathway

1 reference

8 April 2019

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

positive regulation of cytosolic calcium ion concentration

1 reference

10 September 2018

Cloning and characterization of a human angiotensin II type 1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30556&geneProductId=UniProtKB:P30556

angiotensin-activated signaling pathway

1 reference

8 April 2019

Cloning and characterization of a human angiotensin II type 1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

renin-angiotensin regulation of aldosterone production

1 reference

8 April 2019

Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of macrophage derived foam cell differentiation

1 reference

8 April 2019

Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

positive regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

regulation of vasoconstriction

4 references

8 April 2019

Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

low-density lipoprotein particle remodeling

1 reference

8 April 2019

Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

regulation of cell population proliferation

1 reference

8 April 2019

Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

regulation of cell growth

1 reference

8 April 2019

Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

Rho protein signal transduction

1 reference

8 April 2019

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

positive regulation of NAD(P)H oxidase activity

1 reference

8 April 2019

Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

regulation of inflammatory response

1 reference

8 April 2019

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

1 reference

8 April 2019

Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

regulation of systemic arterial blood pressure by renin-angiotensin

1 reference

8 April 2019

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

calcium-mediated signaling

1 reference

8 April 2019

Cloning and characterization of a human angiotensin II type 1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

blood vessel diameter maintenance

IEA

1 reference

8 April 2019

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

G protein-coupled receptor signaling pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

8 April 2019

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

8 April 2019

MicroRNA-155 Exerts Cell-Specific Antiangiogenic but Proarteriogenic Effects During Adaptive Neovascularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

IGI

inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30556

physically interacts with

IBA

1 reference

587

17 August 2016

1 reference

588

17 August 2016

1 reference

589

17 August 2016

1 reference

590

17 August 2016

1 reference

6898

17 August 2016

1 reference

592

17 August 2016

1 reference

3937

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2028661

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL432162

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1069

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL57242

candesartan cilexetil

object has role

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1014

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL539423

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL41194

Gene Atlas image

PBB GE AGTR1 205357 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30556

Identifiers

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

9.A.14.13.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database