Expression and Molecular Pharmacology of the Mouse CRTH2 Receptor (Q28195805)

https://api.crossref.org/works/10.1124/JPET.103.050955

28 December 2023

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https://api.crossref.org/works/10.1124/JPET.103.050955

28 December 2023

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Aaron N. Hata

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12721327

28 December 2023

author name string

Roy Zent

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Matthew D. Breyer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12721327

28 December 2023

Richard M. Breyer

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1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12721327

28 December 2023

language of work or name

English

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publication date

August 2003

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29 April 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12721327

full work available at URL

28 December 2023

https://syndication.highwire.org/content/doi/10.1124/jpet.103.050955

1 reference

https://api.crossref.org/works/10.1124/JPET.103.050955

Journal of Pharmacology and Experimental Therapeutics

28 December 2023

published in

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volume

306

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issue

2

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page(s)

463-70

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cites work

Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family

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https://api.crossref.org/works/10.1124/JPET.103.050955

The release of prostaglandin D2 from human skin in vivo and in vitro during immediate allergic reactions

28 December 2023

2

1 reference

https://api.crossref.org/works/10.1124/JPET.103.050955

Molecular Cloning and Characterization of the Human Prostanoid DP Receptor

28 December 2023

3

1 reference

https://api.crossref.org/works/10.1124/JPET.103.050955

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

28 December 2023

4

1 reference

https://api.crossref.org/works/10.1124/JPET.103.050955

CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease

28 December 2023

5

1 reference

https://api.crossref.org/works/10.1124/JPET.103.050955

The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation

28 December 2023

6

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https://api.crossref.org/works/10.1124/JPET.103.050955

Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea

28 December 2023

7

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https://api.crossref.org/works/10.1124/JPET.103.050955

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

28 December 2023

8

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https://api.crossref.org/works/10.1124/JPET.103.050955

Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice

28 December 2023

9

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https://api.crossref.org/works/10.1124/JPET.103.050955

Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor

28 December 2023

10

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https://api.crossref.org/works/10.1124/JPET.103.050955

Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP

28 December 2023

11

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https://api.crossref.org/works/10.1124/JPET.103.050955

The biology and pharmacology of PGD2.

28 December 2023

12

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https://api.crossref.org/works/10.1124/JPET.103.050955

The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men.

28 December 2023

13

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https://api.crossref.org/works/10.1124/JPET.103.050955

15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway

28 December 2023

14

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https://api.crossref.org/works/10.1124/JPET.103.050955

Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2

28 December 2023

15

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https://api.crossref.org/works/10.1124/JPET.103.050955

Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

28 December 2023

16

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https://api.crossref.org/works/10.1124/JPET.103.050955

Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene

28 December 2023

17

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https://api.crossref.org/works/10.1124/JPET.103.050955

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

28 December 2023

18

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https://api.crossref.org/works/10.1124/JPET.103.050955

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

28 December 2023

19

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https://api.crossref.org/works/10.1124/JPET.103.050955

Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

28 December 2023

20

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https://api.crossref.org/works/10.1124/JPET.103.050955

MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive ox

28 December 2023

21

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https://api.crossref.org/works/10.1124/JPET.103.050955

Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling.

28 December 2023

23

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https://api.crossref.org/works/10.1124/JPET.103.050955

Prostaglandin D2 as a mediator of allergic asthma

28 December 2023

24

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https://api.crossref.org/works/10.1124/JPET.103.050955

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

28 December 2023

25

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https://api.crossref.org/works/10.1124/JPET.103.050955

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase

28 December 2023

26

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https://api.crossref.org/works/10.1124/JPET.103.050955

15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophils

28 December 2023

27

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https://api.crossref.org/works/10.1124/JPET.103.050955

Release of prostaglandin D2 into human airways during acute antigen challenge

28 December 2023

29

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https://api.crossref.org/works/10.1124/JPET.103.050955

CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)

28 December 2023

30

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https://api.crossref.org/works/10.1124/JPET.103.050955

Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs

28 December 2023

31

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https://api.crossref.org/works/10.1124/JPET.103.050955

The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils

28 December 2023

32

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https://api.crossref.org/works/10.1124/JPET.103.050955

EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibitio

28 December 2023

33

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https://api.crossref.org/works/10.1124/JPET.103.050955

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

28 December 2023

35

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https://api.crossref.org/works/10.1124/JPET.103.050955

15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes

28 December 2023

36

1 reference

https://api.crossref.org/works/10.1124/JPET.103.050955

Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils

28 December 2023

37

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https://api.crossref.org/works/10.1124/JPET.103.050955

Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival

28 December 2023

38

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https://api.crossref.org/works/10.1124/JPET.103.050955

Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism

28 December 2023

39

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https://api.crossref.org/works/10.1124/JPET.103.050955

Interleukin-13: central mediator of allergic asthma

28 December 2023

40

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https://api.crossref.org/works/10.1124/JPET.103.050955

28 December 2023

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