Tumor necrosis factor receptor-associated factors (TRAFs) (Q28199382)

RAIDD is a new 'death' adaptor molecule

Europe PubMed Central

title

Tumor necrosis factor receptor-associated factors (TRAFs) (English)

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author name string

J R Bradley

series ordinal

1

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J S Pober

series ordinal

2

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language of work or name

English

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publication date

1 October 2001

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published in

Oncogene

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volume

20

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page(s)

6482-91

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issue

44

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cites work

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Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation

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CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase

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4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB

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Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily

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Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kappaB activation

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TRAF6 is a signal transducer for interleukin-1

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TRAF1 is a TNF inducible regulator of NF-kappaB activation.

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Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins

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TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.

21 January 2018

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Involvement of CRAF1, a relative of TRAF, in CD40 signaling

21 January 2018

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FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

21 January 2018

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Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment

21 January 2018

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Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses.

21 January 2018

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Membrane localization of TRAF 3 enables JNK activation

21 January 2018

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

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Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation

21 January 2018

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Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2.

21 January 2018

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Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors

21 January 2018

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Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor

21 January 2018

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The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily

21 January 2018

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CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins

21 January 2018

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TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase

21 January 2018

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Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.

21 January 2018

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Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)

21 January 2018

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TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

21 January 2018

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

21 January 2018

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TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling

21 January 2018

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Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region

21 January 2018

1 reference

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Expression of the tumor necrosis factor receptor-associated factors (TRAFs) 1 and 2 is a characteristic feature of Hodgkin and Reed-Sternberg cells

21 January 2018

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Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death

21 January 2018

1 reference

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AP-1 function and regulation

21 January 2018

1 reference

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ASK1 is essential for JNK/SAPK activation by TRAF2

21 January 2018

1 reference

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Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein

21 January 2018

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Assembly and regulation of the CD40 receptor complex in human B cells

21 January 2018

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Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand

21 January 2018

1 reference

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VP4 differentially regulates TRAF2 signaling, disengaging JNK activation while directing NF-kappa B to effect rotavirus-specific cellular responses

21 January 2018

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Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation

21 January 2018

1 reference

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TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation

21 January 2018

1 reference

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CD30/TNF receptor-associated factor interaction: NF-kappa B activation and binding specificity

21 January 2018

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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

21 January 2018

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Purification and characterization of the human interleukin-18 receptor

21 January 2018

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TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis

21 January 2018

1 reference

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Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation.

21 January 2018

1 reference

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Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2.

21 January 2018

1 reference

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MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network

21 January 2018

1 reference

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T6BP, a TRAF6-interacting protein involved in IL-1 signaling

21 January 2018

1 reference

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

21 January 2018

1 reference

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

21 January 2018

1 reference

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Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40

21 January 2018

1 reference

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Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1

21 January 2018

1 reference

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Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development

21 January 2018

1 reference

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RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase

21 January 2018

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Myxoma T2 protein as a model for poxvirus TNF receptor homologs

21 January 2018

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Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family

21 January 2018

1 reference

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A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

21 January 2018

1 reference

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The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

1 reference

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The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

21 January 2018

1 reference

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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor

21 January 2018

1 reference

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Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation

21 January 2018

1 reference

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Structural basis for self-association and receptor recognition of human TRAF2

21 January 2018

1 reference

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CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs). Binding site specificity and activation of downstream pathways by distinct TRAFs

21 January 2018

1 reference

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CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization

21 January 2018

1 reference

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Identification and characterization of an IkappaB kinase

21 January 2018

1 reference

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Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma

21 January 2018

1 reference

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

21 January 2018

1 reference

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A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

21 January 2018

1 reference

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I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction

21 January 2018

1 reference

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A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

Localization of the major NF-kappaB-activating site and the sole TRAF3 binding site of LMP-1 defines two distinct signaling motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

inferred from DOI database lookup

7 January 2021

based on heuristic

TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788

inferred from DOI database lookup

7 January 2021

based on heuristic

The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204788