Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe (Q28201516)

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9 November 2019

title

Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe (English)

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9 November 2019

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GOA release 2020-03-11

author

Kenneth D. Irvine

5

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9 November 2019

author name string

Vladislav M Panin

1

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9 November 2019

Li Shao

2

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9 November 2019

Liang Lei

3

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9 November 2019

Daniel J Moloney

4

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9 November 2019

Robert S Haltiwanger

6

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9 November 2019

language of work or name

English

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publication date

29 May 2002

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Journal of Biological Chemistry

9 November 2019

published in

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9 November 2019

volume

277

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9 November 2019

issue

33

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9 November 2019

page(s)

29945-29952

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Notch signaling: cell fate control and signal integration in development

9 November 2019

cites work

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Fringe, Notch, and making developmental boundaries.

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Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.

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Fringe is a glycosyltransferase that modifies Notch

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The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD.

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Fringe modulates Notch-ligand interactions.

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Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila

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Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.

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Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation

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Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules

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Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1

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O-linked fucose and other post-translational modifications unique to EGF modules

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Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase

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Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells

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C-mannosylation and O-fucosylation of the thrombospondin type 1 module

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Isolation and structural determination of three peptides from the insect Locusta migratoria. Identification of a deoxyhexose-linked peptide

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Solution structure of PMP-C: a new fold in the group of small serine proteinase inhibitors

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The O-linked fucose glycosylation pathway: identification and characterization of a uridine diphosphoglucose: fucose-beta1,3-glucosyltransferase activity from Chinese hamster ovary cells

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Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

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Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

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21 January 2018

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A simple method for site-directed mutagenesis using the polymerase chain reaction

21 January 2018

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Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway

21 January 2018

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Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus

21 January 2018

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Fringe forms a complex with Notch

21 January 2018

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Identifiers

DOI

10.1074/JBC.M204445200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12036964%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference