Molecular mechanisms of human single-minded 2 (SIM2) gene expression: identification of a promoter site in the SIM2 genomic sequence (Q28201611)

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J Tochigi

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J Kudoh

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S Minoshima

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N Shimizu

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Y Shimizu

Human BAC library: construction and rapid screening

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language of work or name

English

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publication date

30 May 2001

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published in

Gene

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volume

270

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issue

1-2

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page(s)

265-75

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cites work

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Single-minded and Down syndrome?

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Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region

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Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

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The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product

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Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development

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Molecular mapping of twenty-four features of Down syndrome on chromosome 21.

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Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis

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cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization.

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Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome

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Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome

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Nucleotide preferences in sequence-specific recognition of DNA by c-mybprotein

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Tubulogenesis in Drosophila: a requirement for the trachealess gene product

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Molecular genetic approach to the characterization of the "Down syndrome region" of chromosome 21.

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Characterization of msim, a murine homologue of the Drosophila sim transcription factor.

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A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

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The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells

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The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

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An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers

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Isolation and characterization of mutations in the human holocarboxylase synthetase cDNA

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The DNA sequence of human chromosome 21

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Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system

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TRANSFAC: a database on transcription factors and their DNA binding sites

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The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome

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