Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation (Q28204294)

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

Europe PubMed Central

title

Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation (English)

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author name string

Simon N Powell

series ordinal

1

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Lisa A Kachnic

series ordinal

2

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language of work or name

English

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publication date

1 September 2003

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published in

Oncogene

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volume

22

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issue

37

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page(s)

5784-91

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cites work

1 reference

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Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium

21 January 2018

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Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

21 January 2018

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Developmental studies of Brca1 and Brca2 knock-out mice

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BRCA1 and BRCA2--breast cancer susceptibility genes

21 January 2018

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Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations

21 January 2018

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The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

21 January 2018

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Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage

21 January 2018

1 reference

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Direct DNA binding by Brca1

21 January 2018

1 reference

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BRCA1 is a component of the RNA polymerase II holoenzyme

21 January 2018

1 reference

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Independence of R/M/N focus formation and the presence of intact BRCA1.

21 January 2018

1 reference

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Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

21 January 2018

1 reference

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BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines

21 January 2018

1 reference

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Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control

21 January 2018

1 reference

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7 January 2021

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

1 reference

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7 January 2021

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

1 reference

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7 January 2021

p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

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7 January 2021

p53 mutations in BRCA1-associated familial breast cancer

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Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium

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BRCA1 required for transcription-coupled repair of oxidative DNA damage

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The fuss about Mus81.

1 reference

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Activation of transcription in vitro by the BRCA1 carboxyl-terminal domain

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The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

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Linkage of early-onset familial breast cancer to chromosome 17q21

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Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

1 reference

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The expanding role of cell cycle regulators.

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Cancer-susceptibility genes. Gatekeepers and caretakers

1 reference

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BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression

1 reference

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7 January 2021

A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression

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7 January 2021

The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase

1 reference

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7 January 2021

BRCA2 is required for homology-directed repair of chromosomal breaks

1 reference

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7 January 2021

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

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7 January 2021

Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer

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7 January 2021

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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7 January 2021

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.

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7 January 2021

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.

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7 January 2021

BRCA1 signals ARF-dependent stabilization and coactivation of p53.

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7 January 2021

Identification of the breast cancer susceptibility gene BRCA2

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7 January 2021

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

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7 January 2021

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

1 reference

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7 January 2021

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206678

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

5033191

1026442022

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5033191

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference