Defensins: antimicrobial peptides of innate immunity (Q28204453)

Nature Reviews Immunology

Europe PubMed Central

title

Defensins: antimicrobial peptides of innate immunity (English)

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main subject

antimicrobial peptide

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Tomas Ganz

1

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language of work or name

English

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publication date

September 2003

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published in

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volume

3

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issue

9

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page(s)

710-20

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cites work

Defensins. Natural peptide antibiotics of human neutrophils

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Primary structures of three human neutrophil defensins

31 March 2020

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Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain

31 March 2020

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Cathelicidins: a family of endogenous antimicrobial peptides

31 March 2020

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Human salivary histatins: promising anti-fungal therapeutic agents

31 March 2020

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Dermcidin: a novel human antibiotic peptide secreted by sweat glands

31 March 2020

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ANTIBACTERIAL AND ENZYMIC BASIC PROTEINS FROM LEUKOCYTE LYSOSOMES: SEPARATION AND IDENTIFICATION

31 March 2020

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Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium

31 March 2020

1 reference

Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.

31 March 2020

1 reference

Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization

31 March 2020

1 reference

Solution structures of the rabbit neutrophil defensin NP-5.

31 March 2020

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NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1

31 March 2020

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NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1

31 March 2020

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Structure and dynamics of the neutrophil defensins NP-2, NP-5, and HNP-1: NMR studies of amide hydrogen exchange kinetics

31 March 2020

1 reference

Solution structure of bovine neutrophil beta-defensin-12: the peptide fold of the beta-defensins is identical to that of the classical defensins

31 March 2020

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The structure of human beta-defensin-2 shows evidence of higher order oligomerization

31 March 2020

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The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment

31 March 2020

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A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins

31 March 2020

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Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1.

31 March 2020

1 reference

The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry

31 March 2020

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Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes

31 March 2020

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Gallinacin-3, an inducible epithelial beta-defensin in the chicken

31 March 2020

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Isolation of antimicrobial peptides from avian heterophils.

31 March 2020

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Characterization of beta-defensin prepropeptide mRNA from chicken and turkey bone marrow.

31 March 2020

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Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria

31 March 2020

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Human beta-defensin-1: an antimicrobial peptide of urogenital tissues

31 March 2020

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A peptide antibiotic from human skin

31 March 2020

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Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins

31 March 2020

1 reference

Cloning and expression of bovine neutrophil beta-defensins. Biosynthetic profile during neutrophilic maturation and localization of mature peptide to novel cytoplasmic dense granules.

31 March 2020

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Epithelial antibiotics induced at sites of inflammation

31 March 2020

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Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids

31 March 2020

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Assignment of defensin gene(s) to human chromosome 8p23

31 March 2020

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Mapping of the gene encoding human beta-defensin-2 (DEFB2) to chromosome region 8p22-p23.1

31 March 2020

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Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation

31 March 2020

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A 450-kb contig of defensin genes on human chromosome 8p23.

31 March 2020

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Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3.

31 March 2020

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Discovery of five conserved beta -defensin gene clusters using a computational search strategy

31 March 2020

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Unmasking and redistribution of lysosomal sulfated glycoconjugates in phagocytic polymorphonuclear leukocytes

31 March 2020

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Acid mucosubstance and basic protein in mouse Paneth cells

31 March 2020

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Electrostatic interactions between human leukocyte elastase and sulfated glycosaminoglycans: physiological implications

31 March 2020

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Differences in the interaction of heparin with arginine and lysine and the importance of these basic amino acids in the binding of heparin to acidic fibroblast growth factor

31 March 2020

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Isolation and characterization of human defensin cDNA clones

31 March 2020

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Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?

31 March 2020

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Intramolecular inhibition of human defensin HNP-1 by its propiece

31 March 2020

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Timing, targeting and sorting of azurophil granule proteins in human myeloid cells

31 March 2020

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The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules.

31 March 2020

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Paneth cell trypsin is the processing enzyme for human defensin-5.

31 March 2020

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In human epidermis, beta-defensin 2 is packaged in lamellar bodies

31 March 2020

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The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes

31 March 2020

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Human enteric defensins. Gene structure and developmental expression

31 March 2020

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Differentiation-stimulated activity binds an ETS-like, essential regulatory element in the human promyelocytic defensin-1 promoter

31 March 2020

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By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide

31 March 2020

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Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production

31 March 2020

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Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors

31 March 2020

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Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity

31 March 2020

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Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells

31 March 2020

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Epithelial antibiotic induced in states of disease

31 March 2020

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Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations

31 March 2020

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Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor.

31 March 2020

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Mechanism of mammalian cell lysis mediated by peptide defensins. Evidence for an initial alteration of the plasma membrane

31 March 2020

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Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion.

31 March 2020

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Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity

31 March 2020

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Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes

31 March 2020

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Defensins promote fusion and lysis of negatively charged membranes

31 March 2020

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Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores

31 March 2020

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Differential Scanning Microcalorimetry Indicates That Human Defensin, HNP-2, Interacts Specifically with Biomembrane Mimetic Systems†,‡

31 March 2020

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Retrocyclin, an Antiretroviral θ-Defensin, Is a Lectin

31 March 2020

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Action of antimicrobial peptides: two-state model

31 March 2020

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Why and how are peptide-lipid interactions utilized for self defence?

31 March 2020

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Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides

31 March 2020

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Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense

31 March 2020

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Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

31 March 2020

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Characterization of the mouse beta defensin 1, Defb1, mutant mouse model.

31 March 2020

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beta-Defensin 1 contributes to pulmonary innate immunity in mice

31 March 2020

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Innate antimicrobial peptide protects the skin from invasive bacterial infection

31 March 2020

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Salmonella typhimurium phoP virulence gene is a transcriptional regulator

31 March 2020

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PhoP/PhoQ: macrophage-specific modulators ofSalmonellavirulence?

31 March 2020

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Molecular genetic analysis of the Escherichia coli phoP locus

31 March 2020

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Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides.

31 March 2020

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A PhoP-regulated outer membrane protease of Salmonella enterica serovar typhimurium promotes resistance to alpha-helical antimicrobial peptides.

31 March 2020

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Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family

31 March 2020

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Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides

31 March 2020

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Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine

31 March 2020

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Monocyte-chemotactic activity of defensins from human neutrophils

31 March 2020

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Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils

31 March 2020

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Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6

31 March 2020

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Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.

31 March 2020

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The corticostatic (anti-ACTH) and cytotoxic activity of peptides isolated from fetal, adult and tumor-bearing lung

31 March 2020

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Isolation and biological activity of corticostatic peptides (anti-ACTH).

31 March 2020

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31 March 2020

Corticostatic peptides

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Effects of corticostatin-I on rat adrenal cells in vitro

31 March 2020

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Corticostatic peptides cause nifedipine-sensitive volume reduction in jejunal villus enterocytes

31 March 2020

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The isolation and characterization of a novel corticostatin/defensin-like peptide from the kidney.

31 March 2020

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Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3.

31 March 2020

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Cryptdin-3 induces novel apical conductance(s) in Cl- secretory, including cystic fibrosis, epithelia

31 March 2020

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Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid.

31 March 2020

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Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

31 March 2020

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The genesis of cystic fibrosis lung disease

31 March 2020

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Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease

31 March 2020

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Genetic variants of human beta-defensin-1 and chronic obstructive pulmonary disease.

31 March 2020

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Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: high-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls

31 March 2020

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Refined three-dimensional solution structure of insect defensin A

31 March 2020

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Defensin-rich granules of human neutrophils: characterization of secretory properties.

31 March 2020

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Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel

31 March 2020

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hBD-1: a novel beta-defensin from human plasma

31 March 2020

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Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic

31 March 2020

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Expression of human alpha-defensin 5 (HD5) mRNA in nasal and bronchial epithelial cells

31 March 2020

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Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans.

31 March 2020

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Murine beta-defensin-3 is an inducible peptide with limited tissue expression and broad-spectrum antimicrobial activity

31 March 2020

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The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1.

31 March 2020

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A novel murine beta -defensin expressed in tongue, esophagus, and trachea.

31 March 2020

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Mouse beta defensin-1 is a functional homolog of human beta defensin-1

31 March 2020

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A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide.

31 March 2020

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Testis-specific expression of a novel mouse defensin-like gene, Tdl.

31 March 2020

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Molecular cloning and tissue expression of porcine beta-defensin-1.

31 March 2020

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Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils

31 March 2020

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Isolation of human intestinal defensins from ileal neobladder urine

31 March 2020

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Bethanechol and a G-protein activator, NaF/AlCl3, induce secretory response in Paneth cells of mouse intestine

31 March 2020

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Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells

31 March 2020

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Small, anionic, and charge-neutralizing propeptide fragments of zymogens are antimicrobial

31 March 2020

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7 January 2021

Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations

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7 January 2021

Activity of rabbit leukocyte peptides against Candida albicans

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7 January 2021

Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes

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7 January 2021

Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium

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7 January 2021

Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes

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7 January 2021

Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs.

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7 January 2021

Identifiers

DOI

10.1038/NRI1180

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

653474

1046714829

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653474

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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