The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders (Q28205399)

Genetic classification of primary neurodegenerative disease

Europe PubMed Central

title

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders (English)

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K K Chung

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V L Dawson

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T M Dawson

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3

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language of work or name

English

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publication date

November 2001

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published in

Trends in Neurosciences

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volume

24

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issue

11 Suppl

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page(s)

S7-14

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cites work

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Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.

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The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

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The septin CDCrel-1 binds syntaxin and inhibits exocytosis

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Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins

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Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

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Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.

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Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4.

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Ubiquitin pathway: another link in the polyubiquitin chain?

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

11881748

1 reference

Consolidated OpenCitations Corpus – April 2017