Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? (Q28207052)

Nature Reviews Immunology

Europe PubMed Central

title

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? (English)

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author name string

Michael Croft

series ordinal

1

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language of work or name

English

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publication date

August 2003

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published in

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volume

3

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issue

8

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page(s)

609-20

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cites work

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A TNF family member LIGHT transduces costimulatory signals into human T cells

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Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation

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The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2

31 March 2020

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Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B

31 March 2020

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CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand

31 March 2020

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Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1

31 March 2020

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4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1.

31 March 2020

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4-1BB co-stimulation enhances human CD8(+) T cell priming by augmenting the proliferation and survival of effector CD8(+) T cells

31 March 2020

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31 March 2020

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IkappaB kinases serve as a target of CD28 signaling

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy

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31 March 2020

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31 March 2020

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OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation

31 March 2020

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31 March 2020

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Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses

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Costimulation of human CD28- T cells by 4-1BB ligand

31 March 2020

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Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.

31 March 2020

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Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

31 March 2020

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Transcriptional mechanisms underlying lymphocyte tolerance.

31 March 2020

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Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis

31 March 2020

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Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice

31 March 2020

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Involvement of CD70-CD27 interactions in the induction of experimental autoimmune encephalomyelitis

31 March 2020

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Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis

31 March 2020

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Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells

31 March 2020

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Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis

31 March 2020

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Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

31 March 2020

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CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.

31 March 2020

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The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

31 March 2020

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LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer

31 March 2020

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CD40 and CD70 co-stimulate a potent in vivo antitumor T cell response.

31 March 2020

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Engagement of the OX-40 receptor in vivo enhances antitumor immunity

31 March 2020

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OX40 ligation enhances primary and memory cytotoxic T lymphocyte responses in an immunotherapy for hepatic colon metastases

31 March 2020

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OX40 ligand-transduced tumor cell vaccine synergizes with GM-CSF and requires CD40-Apc signaling to boost the host T cell antitumor response

31 March 2020

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Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic, major histocompatibility complex class I-negative A9P melanoma

31 March 2020

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Tumour rejection by gene transfer of 4-1BB ligand into a CD80(+) murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells

31 March 2020

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Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

31 March 2020

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Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB.

31 March 2020

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