Structure-based studies on species-specific inhibition of thymidylate synthase (Q28207390)

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10 November 2019

review article

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title

Structure-based studies on species-specific inhibition of thymidylate synthase (English)

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10 November 2019

1

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10 November 2019

Donatella Tondi

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10 November 2019

author name string

Marcella Rinaldi

3

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10 November 2019

Daniela Barlocco

4

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10 November 2019

Piergiorgio Pecorari

5

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10 November 2019

Fabrizia Soragni

6

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10 November 2019

Alberto Venturelli

7

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10 November 2019

Robert M Stroud

8

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10 November 2019

language of work or name

English

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publication date

1 July 2002

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Biochimica et Biophysica Acta

10 November 2019

published in

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10 November 2019

volume

1587

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10 November 2019

issue

2-3

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10 November 2019

page(s)

206-214

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Update on antifolate drugs targets

10 November 2019

cites work

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Finding drug targets in microbial genomes

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Structure-based library design: molecular modelling merges with combinatorial chemistry

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7 January 2021

The catalytic mechanism and structure of thymidylate synthase

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7 January 2021

Effect of 2'-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells

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7 January 2021

The role of thymidylate synthase as an RNA binding protein

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7 January 2021

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors

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7 January 2021

Orientational sampling and rigid-body minimization in molecular docking

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7 January 2021

Automated docking with grid-based energy evaluation

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7 January 2021

Structure-based discovery of inhibitors of thymidylate synthase

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7 January 2021

Molecular docking using shape descriptors

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7 January 2021

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

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7 January 2021

Design of enzyme inhibitors using iterative protein crystallographic analysis

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7 January 2021

Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase

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7 January 2021

Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis

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7 January 2021

Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.

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7 January 2021

Thymidylate synthase inhibition: a structure-based rationale for drug design

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7 January 2021

Crystallization of human thymidylate synthase

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7 January 2021

Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site

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7 January 2021

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug

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7 January 2021

Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases

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7 January 2021

Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking

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7 January 2021

Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines

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7 January 2021

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition

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7 January 2021

Structure-based design of inhibitors specific for bacterial thymidylate synthase

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7 January 2021

Structure-based discovery and in-parallel optimization of novelcompetitive inhibitors of thymidylate synthase

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7 January 2021

Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase1,21Escherichia coli thymidylate synthase numbering is used unless otherwise noted.2PDB coordinates have been deposited with the RCSB wi

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7 January 2021

10.1016/S0925-4439(02)00083-2

Identifiers

DOI

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10 November 2019

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