Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B (Q28207582)

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F S Hung

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D S Chan

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P C Shaw

GLQ223: an inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage

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language of work or name

English

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publication date

April 2001

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published in

FEBS Journal

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volume

268

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issue

7

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page(s)

2107-12

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cites work

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Minireview: trichosanthin--a protein with multiple pharmacological properties

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Structure/function relationship study of Gln156, Glu160 and Glu189 in the active site of trichosanthin.

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Cloning of trichosanthin cDNA and its expression in Escherichia coli

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Lowering of trichosanthin immunogenicity by site-specific coupling to dextran

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Reducing the immunogenicity and improving the in vivo activity of trichosanthin by site-directed pegylation.

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The effect of an antiviral peptide on the ribosomal reactions of the peptide elongation enzymes, EF-I and EF-II.

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Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA.

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Evidence that the G2661 region of 23S rRNA is located at the ribosomal binding sites of both elongation factors.

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The ribosome-in-pieces: binding of elongation factor EF-G to oligoribonucleotides that mimic the sarcin/ricin and thiostrepton domains of 23S ribosomal RNA.

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Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus

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Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly

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Characterization of MAD2B and other mitotic spindle checkpoint genes

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A ribosomal protein is specifically recognized by saporin, a plant toxin which inhibits protein synthesis

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Pokeweed antiviral protein accesses ribosomes by binding to L3.

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Ribosomal Acidic Phosphoproteins P1 and P2 Are Not Required for Cell Viability but Regulate the Pattern of Protein Expression in Saccharomyces cerevisiae

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Topography and stoichiometry of acidic proteins in large ribosomal subunits from Artemia salina as determined by crosslinking

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A specific role for the phosphorylation of mammalian acidic ribosomal protein P2

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Binding of mammalian ribosomal protein complex P0.P1.P2 and protein L12 to the GTPase-associated domain of 28 S ribosomal RNA and effect on the accessibility to anti-28 S RNA autoantibody

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A phase II study of effect of addition of trichosanthin to zidovudine in patients with HIV disease and failing antiretroviral agents

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High level synthesis of biologically active recombinant trichosanthin in Escherichia coli

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Structure/function relationship study of Tyr14 and Arg22 in trichosanthin, a ribosome-inactivating protein

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The antigenic sites of trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties

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Increasing the plasma half-life of trichosanthin by coupling to dextran

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Site-directed polyethylene glycol modification of trichosanthin: effects on its biological activities, pharmacokinetics, and antigenicity

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Engineering of a mini-trichosanthin that has lower antigenicity by deleting its C-terminal amino acid residues

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The highly conserved protein P0 carboxyl end is essential for ribosome activity only in the absence of proteins P1 and P2

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Ricin A chain can be chemically cross-linked to the mammalian ribosomal proteins L9 and L10e

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Interaction of elongation factor eEF-2 with ribosomal P proteins

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Replacement of L7/L12.L10 protein complex in Escherichia coli ribosomes with the eukaryotic counterpart changes the specificity of elongation factor binding

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The RNA interacting domain but not the protein interacting domain is highly conserved in ribosomal protein P0

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