Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system (Q28208143)

9

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Xavier Altafaj

object named as

Xavier Altafaj

2

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Susana de la Luna

object named as

Susana de la Luna

4

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Mara Dierssen Sotos

object named as

Mara Dierssen

3

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author name string

Eulàlia Martí

1

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Vassiliki Fotaki

5

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Mónica Alvarez

6

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Mercè Pérez-Riba

7

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Isidro Ferrer

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

8

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language of work or name

English

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publication date

28 February 2003

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published in

Brain Research

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volume

964

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issue

2

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page(s)

250-63

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cites work

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Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases

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Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate

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Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

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Coactivation of secretogranin-II and BDNF genes mediated by calcium signals in mouse cerebellar granule cells

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Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase

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The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle

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mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development

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A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

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Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome

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Specificity determinants of substrate recognition by the protein kinase DYRK1A

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Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

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Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

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Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21

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Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

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The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers

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The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

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The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12576186

1 reference

Consolidated OpenCitations Corpus – April 2017