Mechanisms and functions of Eph and ephrin signalling (Q28208291)

Nature Reviews Molecular Cell Biology

Europe PubMed Central

title

Mechanisms and functions of Eph and ephrin signalling (English)

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1

Klas Kullander

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author name string

Rüdiger Klein

series ordinal

2

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language of work or name

English

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publication date

July 2002

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published in

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volume

3

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page(s)

475-86

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issue

7

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cites work

Eph receptors and ephrins restrict cell intermingling and communication.

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Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands

31 March 2020

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Tyrosine phosphorylation of transmembrane ligands for Eph receptors

31 March 2020

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Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity

31 March 2020

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Multiple in vivo tyrosine phosphorylation sites in EphB receptors

31 March 2020

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Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors

31 March 2020

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Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses

31 March 2020

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Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo.

31 March 2020

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Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region

31 March 2020

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Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events

31 March 2020

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Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons

31 March 2020

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Signaling through scaffold, anchoring, and adaptor proteins

31 March 2020

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Cycling, stressed-out and nervous: cellular functions of c-Abl

31 March 2020

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Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor

31 March 2020

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c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

31 March 2020

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Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region

31 March 2020

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Essential roles for the Abl and Arg tyrosine kinases in neurulation

31 March 2020

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Regulation of repulsion versus adhesion by different splice forms of an Eph receptor

31 March 2020

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Rho GTPases and the actin cytoskeleton

31 March 2020

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Rho GTPases in neuronal morphogenesis

31 March 2020

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Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid

31 March 2020

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EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin

31 March 2020

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Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase

31 March 2020

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Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway

31 March 2020

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Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction

31 March 2020

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Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase

31 March 2020

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Functional activation of EphA5 receptor does not promote cell proliferation in the aberrant EphA5 expressing human glioblastoma U-118 MG cell line

31 March 2020

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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

31 March 2020

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An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

31 March 2020

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

31 March 2020

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Integrin signalling and tyrosine phosphorylation: just the FAKs?

31 March 2020

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An Eph receptor regulates integrin activity through R-Ras

31 March 2020

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Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

31 March 2020

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Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrins

31 March 2020

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Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation

31 March 2020

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The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

31 March 2020

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Signaling by Eph receptors and their ephrin ligands.

31 March 2020

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The ephrins and Eph receptors in neural development

31 March 2020

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Eph receptors and ephrins: regulators of guidance and assembly

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

Nuk controls pathfinding of commissural axons in the mammalian central nervous system

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In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue

31 March 2020

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EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase

31 March 2020

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Fibroblast growth factor receptor-mediated rescue of x-ephrin B1-induced cell dissociation in Xenopus embryos

31 March 2020

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PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands

31 March 2020

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EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains

31 March 2020

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The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif

31 March 2020

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The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals

31 March 2020

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A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions

31 March 2020

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Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity

31 March 2020

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Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity

31 March 2020

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Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction

31 March 2020

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Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha.

31 March 2020

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Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines

31 March 2020

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Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor

31 March 2020

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Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion

31 March 2020

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Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner

31 March 2020

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An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein.

31 March 2020

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The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans

31 March 2020

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EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract

31 March 2020

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Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control

31 March 2020

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Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline

31 March 2020

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Immunolocalization of the receptor tyrosine kinase EphA4 in the adult rat central nervous system.

31 March 2020

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Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses

31 March 2020

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Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites

31 March 2020

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The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization

31 March 2020

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Oligomeric structure of the human EphB2 receptor SAM domain

31 March 2020

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EphB2 guides axons at the midline and is necessary for normal vestibular function

31 March 2020

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EphB receptors interact with NMDA receptors and regulate excitatory synapse formation

31 March 2020

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Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors

31 March 2020

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EphB/syndecan-2 signaling in dendritic spine morphogenesis

31 March 2020

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Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity

31 March 2020

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The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function

31 March 2020

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Bidirectional signals establish boundaries

31 March 2020

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In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins.

31 March 2020

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The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration.

31 March 2020

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The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells.

31 March 2020

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Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth

31 March 2020

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Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration.

31 March 2020

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Functional organization of the yeast proteome by systematic analysis of protein complexes

31 March 2020

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Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

31 March 2020

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Isolation and characterization of Dek, a Drosophila eph receptor protein tyrosine kinase

31 March 2020

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The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans

31 March 2020

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Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation

31 March 2020

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Eph receptors and ephrins in neural development.

31 March 2020

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Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

31 March 2020

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Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4

31 March 2020

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Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development

31 March 2020

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Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells

31 March 2020

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The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization

31 March 2020

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Lipid rafts and signal transduction

31 March 2020

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Structure, development, and plasticity of dendritic spines

31 March 2020

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Dendritic spines shaped by synaptic activity

31 March 2020

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Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

31 March 2020

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Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase

31 March 2020

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Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

31 March 2020

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PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor

31 March 2020

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Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase

31 March 2020

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Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells

31 March 2020

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A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A

31 March 2020

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Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions

31 March 2020

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The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain

31 March 2020

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Crystal structure of an Eph receptor-ephrin complex

31 March 2020

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Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2

31 March 2020

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Crystal structure of an ephrin ectodomain

31 March 2020

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The N-terminal globular domain of Eph receptors is sufficient for ligand binding and receptor signaling

31 March 2020

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Signal transfer by eph receptors

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM856

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

457379

1022336823

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457379

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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