Phase II study of XR5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with advanced ovarian cancer (Q28212508)

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scientific article (publication date: August 2003)

Language	Label	Description	Also known as
English	Phase II study of XR5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with advanced ovarian cancer	scientific article (publication date: August 2003)

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scholarly article

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Phase II study of XR5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with advanced ovarian cancer (English)

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author name string

Christian Dittrich

1

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Veronique Dieras

2

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Pierre Kerbrat

3

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Cornelis Punt

4

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Roberto Sorio

5

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Francesco Caponigro

6

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Xavier Paoletti

7

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Christine de Balincourt

8

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Denis Lacombe

9

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Pierre Fumoleau

10

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language of work or name

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publication date

August 2003

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Investigational New Drugs

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21

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3

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347-52

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Design of DNA intercalators to overcome topoisomerase II-mediated multidrug resistance

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Inhibition of DNA synthesis and DNA fragmentation in stimulated splenocytes by the concerted action of topoisomerase I and II poisons

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Cell line selectivity and DNA breakage properties of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide: role of DNA topoisomerase II.

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Combined inhibition of topoisomerases I and II--is this a worthwhile/feasible strategy?

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Phase I study of the cytotoxic agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Oral etoposide is active against platinum-resistant epithelial ovarian cancer

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Phase II study of XR 5000, an inhibitor of topoisomerases I and II, in advanced colorectal cancer

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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High-dose epirubicin in platinum-pretreated patients with ovarian carcinoma: the EORTC-GCCG experience

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Topotecan for the treatment of advanced epithelial ovarian cancer: an open-label phase II study in patients treated after prior chemotherapy that contained cisplatin or carboplatin and paclitaxel

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Unusual dynamics of killing of cultured Lewis lung cells by the DNA-intercalating antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Etoposide and carboplatin as salvage and first-line therapy in ovarian cancer patients

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Cellular and molecular determinants of cisplatin resistance

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Melphalan versus adriamycin in the treatment of advanced carcinoma of the ovary

1 reference

https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Phase II study of XR5000 (DACA) administered as a 120-h infusion in patients with recurrent glioblastoma multiforme

1 reference

https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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In vitro assessment of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II).

1 reference

https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

based on heuristic

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Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons

1 reference

https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

based on heuristic

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Phase II study of XR 5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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Phase I and pharmacokinetic study of DACA (XR5000): a novel inhibitor of topoisomerase I and II. CRC Phase I/II Committee

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https://pubmed.ncbi.nlm.nih.gov/14578683

12 December 2020

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10.1023/A:1025476813365

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