Unconventional potentiation of gene expression by Ikaros (Q28215914)

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Elizabeth J Heller

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John R Seavitt

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Katia Georgopoulos

Journal of Biological Chemistry

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language of work or name

English

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publication date

12 April 2002

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published in

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volume

277

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issue

15

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page(s)

13007-15

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cites work

Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment

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The role of the Ikaros gene in lymphocyte development and homeostasis

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Control of lymphocyte development by the Ikaros gene family

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The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene

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The Ikaros gene is required for the development of all lymphoid lineages

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Defects in hemopoietic stem cell activity in Ikaros mutant mice

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Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

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Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros

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Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

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Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin

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Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors

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Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system

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Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities

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Generation of antibody diversity in rabbits

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Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin

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Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

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Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

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Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity

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Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

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Ikaros, a lymphoid-cell-specific transcription factor, contributes to the leukemogenic phenotype of a mink cell focus-inducing murine leukemia virus

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Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding

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BRCA1 can stimulate gene transcription by a unique mechanism

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A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites

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Modulation of a transcription factor counteracts heterochromatic gene silencing in Drosophila.

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