Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin (Q28216314)

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Kathryn A Jones

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Baldwin C Mak

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Raymond S Yeung

Archives of Biochemistry and Biophysics

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language of work or name

English

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publication date

15 August 2002

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published in

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volume

404

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issue

2

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page(s)

210-7

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cites work

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

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Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase

7 January 2021

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The TSC1 gene product, hamartin, negatively regulates cell proliferation

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Tuberous sclerosis gene products in proliferation control

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The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

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The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

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Subependymal giant-cell tumor: astrocytic or neuronal?

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Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

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Separation of the intracellular secretory compartment of rat liver and isolated rat hepatocytes in a single step using self-generating gradients of iodixanol

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Association of mitogen-activated protein kinase with the microtubule cytoskeleton

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Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region

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Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex

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Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

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Purification and characterization of smooth muscle cell caveolae

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Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease

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Caveolae and caveolins

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The genetic basis of tuberous sclerosis.

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Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

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Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members

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Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene

7 January 2021

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The tuberous sclerosis 2 gene product can localize to nuclei in a phosphorylation-dependent manner

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Regulation of signal transduction by endocytosis

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Functional rafts in cell membranes

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Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis

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TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

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10.1016/S0003-9861(02)00300-4

7 January 2021

Identifiers

DOI

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Fatcat ID

release_bk72ma43pfhfzjke7sw6q6njvy

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Fatcat

https://api.fatcat.wiki/v0/release/bk72ma43pfhfzjke7sw6q6njvy