Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2 (Q28216341)

WAS/WASL interacting protein family, member 1

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Wiskott-Aldrich syndrome

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Growth factor receptor bound protein 2

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Non-catalytic region of tyrosine kinase adaptor protein 2

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author

Klemens Rottner

8

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Niki Scaplehorn

object named as

Niki Scaplehorn

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Michael Way

object named as

Michael Way

6

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author name string

Stefanie Benesch

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Silvia Lommel

2

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Anika Steffen

3

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Theresia E B Stradal

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Juergen Wehland

Journal of Biological Chemistry

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language of work or name

English

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publication date

4 October 2002

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published in

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volume

277

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issue

40

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page(s)

37771-6

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cites work

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Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome

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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

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Regulation of Wiskott-Aldrich syndrome protein and related molecules

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Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

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Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex

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GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex

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N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility

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Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP.

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Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.

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Actin assembly at membranes controlled by ARF6.

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The large GTPase dynamin regulates actin comet formation and movement in living cells

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Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling.

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A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization

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Kinesin-dependent movement on microtubules precedes actin-based motility of vaccinia virus

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Grb2 and Nck act cooperatively to promote actin-based motility of vaccinia virus

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Surfing pathogens and the lessons learned for actin polymerization.

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Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation

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Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri

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Actin filament nucleation by endosomes, lysosomes and secretory vesicles

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Cytoskeleton: actin and endocytosis--no longer the weakest link

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