Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity (Q28217897)

4

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author name string

Jiefei Tong

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Sabine Elowe

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Piers Nash

Journal of Biological Chemistry

3

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language of work or name

English

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publication date

21 February 2003

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published in

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volume

278

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issue

8

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page(s)

6111-9

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cites work

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SH2 domains, interaction modules and cellular wiring

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK.

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Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP binding

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Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

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SH2 domains recognize specific phosphopeptide sequences

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Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

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Eph receptors and ephrin ligands. essential mediators of vascular development.

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The ephrins and Eph receptors in angiogenesis

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Eph receptors and ephrin ligands: embryogenesis to tumorigenesis

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The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function

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Multiple roles of EPH receptors and ephrins in neural development

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Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors

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In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue

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Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses

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Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction

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Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway

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Nuk controls pathfinding of commissural axons in the mammalian central nervous system

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Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

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Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells

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Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor

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Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation

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A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

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