Ectopic discharge in Abeta afferents as a source of neuropathic pain (Q28236294)

Experimental Brain Research

Europe PubMed Central

title

Ectopic discharge in Abeta afferents as a source of neuropathic pain (English)

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Marshall Devor

1

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language of work or name

English

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publication date

June 2009

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published in

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volume

196

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page(s)

115-28

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issue

1

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exact match

https://scigraph.springernature.com/pub.10.1007/s00221-009-1724-6

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cites work

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Effects of capsaicin on VGSCs in TRPV1-/- mice.

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A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats

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Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model.

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Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections.

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Erythermalgia: molecular basis for an inherited pain syndrome

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Alteration of the second branch of the trigeminal nerve activity following inferior alveolar nerve transection in rats

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Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain

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Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and neuropathic pain.

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Sensory Transduction in Peripheral Nerve Axons Elicits Ectopic Action Potentials

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Regulation of gene expression by action potentials: dependence on complexity in cellular information processing.

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Phenotype and function of somatic primary afferent nociceptive neurones with C-, Adelta- or Aalpha/beta-fibres

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Unexplained peculiarities of the dorsal root ganglion

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Abnormal substance P release from the spinal cord following injury to primary sensory neurons

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Effects of regional anesthesia on phantom limb pain are mirrored in changes in cortical reorganization.

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Mechanical and heat sensitization of cutaneous nociceptors after peripheral inflammation in the rat

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Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats

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Myelinated skin sensory neurons project extensively throughout adult mouse substantia gelatinosa

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Abeta-afferents activate neurokinin-1 receptor in dorsal horn neurons after nerve injury

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Hyperexcitability in sensory neurons of rats selected for high versus low neuropathic pain phenotype

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Chronic back pain is associated with decreased prefrontal and thalamic gray matter density.

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Subthreshold oscillations facilitate neuropathic spike discharge by overcoming membrane accommodation

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Altered tachykinin expression by dorsal root ganglion neurons in a rat model of neuropathic pain

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Effects of gabapentin on spontaneous discharges and subthreshold membrane potential oscillation of type A neurons in injured DRG.

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Mechanisms of paresthesiae, dysesthesiae, and hyperesthesiae: role of Na+ channel heterogeneity

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Cortical origin of pathological pain

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Ketamine blockage of both tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels of rat dorsal root ganglion neurons.

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Characteristics of ectopic discharges in a rat neuropathic pain model

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Novel classes of responsive and unresponsive C nociceptors in human skin

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Na+ channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation.

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Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation.

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Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves

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Time course of substance P expression in dorsal root ganglia following complete spinal nerve transection

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Do central terminals of intact myelinated primary afferents sprout into the superficial dorsal horn of rat spinal cord after injury to a neighboring peripheral nerve?

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Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations.

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Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers

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Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts

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Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats

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Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury

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Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals

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Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy

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Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli

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12 December 2020

Key role of the dorsal root ganglion in neuropathic tactile hypersensibility.

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12 December 2020

Membrane resonance and subthreshold membrane oscillations in mesencephalic V neurons: participants in burst generation.

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12 December 2020

Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers

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The role of the dorsal columns in neuropathic behavior: evidence for plasticity and non-specificity.

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12 December 2020

Sodium channel accumulation in humans with painful neuromas

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12 December 2020

Progressive tactile hypersensitivity after a peripheral nerve crush: non-noxious mechanical stimulus-induced neuropathic pain

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12 December 2020

Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats.

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12 December 2020

Ultrastructure of afferent axon endings in a neuroma

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12 December 2020

Beyond neurons: evidence that immune and glial cells contribute to pathological pain states

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Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans

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12 December 2020

Spinal anaesthesia for patients with previous lower limb amputations.

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12 December 2020

Ketamine blockade of voltage-gated sodium channels: evidence for a shared receptor site with local anesthetics

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12 December 2020

Sensory and sympathetic contributions to nerve injury-induced sensory abnormalities in the rat.

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12 December 2020

Changes in Na(+) channel currents of rat dorsal root ganglion neurons following axotomy and axotomy-induced autotomy.

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12 December 2020

Spontaneous activity of rat dorsal horn cells in spinal segments of sciatic projection following transection of sciatic nerve or of corresponding dorsal roots

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12 December 2020

Postherpetic neuralgia. Are C-nociceptors involved in signalling and maintenance of tactile allodynia?

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12 December 2020

Blockade of voltage-operated neuronal and skeletal muscle sodium channels by S(+)- and R(-)-ketamine

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12 December 2020

Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.

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12 December 2020

Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.

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12 December 2020

Functional modulation of brain sodium channels by cAMP-dependent phosphorylation

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12 December 2020

Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy

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12 December 2020

EphB receptors and ephrin-B ligands regulate spinal sensory connectivity and modulate pain processing.

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12 December 2020

The role of sodium channels in chronic inflammatory and neuropathic pain

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12 December 2020

Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation

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Corticosteroids suppress ectopic neural discharge originating in experimental neuromas.

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Calcitonin gene-related peptide increase in the rat spinal dorsal horn and dorsal column nucleus following peripheral nerve injury: up-regulation in a subpopulation of primary afferent sensory neurons

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12 December 2020

Slow sodium-dependent potential oscillations contribute to ectopic firing in mammalian demyelinated axons.

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12 December 2020

Time-dependent effect of epidural steroid on pain behavior induced by chronic compression of dorsal root ganglion in rats

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12 December 2020

Nociceptive response to innocuous mechanical stimulation is mediated via myelinated afferents and NK-1 receptor activation in a rat model of neuropathic pain.

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12 December 2020

Myelinated afferents signal the hyperalgesia associated with nerve injury.

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12 December 2020

Spread of excitation across modality borders in spinal dorsal horn of neuropathic rats

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12 December 2020

Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats

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12 December 2020

Unsolved mysteries in membrane traffic

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12 December 2020

Correlational analysis for identifying genes whose regulation contributes to chronic neuropathic pain

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12 December 2020

Calcitonin Gene-related Peptide Causes Intraspinal Spreading of Substance P Released by Peripheral Stimulation.

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12 December 2020

Neuropathic pain: early spontaneous afferent activity is the trigger

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12 December 2020

Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca(2+) signalling in hippocampal neurons.

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12 December 2020

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

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12 December 2020

Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptor.

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12 December 2020

Ectopic mechanosensitivity in injured sensory axons arises from the site of spontaneous electrogenesis.

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12 December 2020

Inhibition of paclitaxel-induced A-fiber hypersensitization by gabapentin.

1 reference

12 December 2020

Chair's introduction: sodium channels and neuronal dysfunction--emerging concepts, converging themes

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12 December 2020

Spinal nerve injury enhances subthreshold membrane potential oscillations in DRG neurons: relation to neuropathic pain.

1 reference

12 December 2020

Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats

1 reference

12 December 2020

Spontaneous discharge and increased heat sensitivity of rat C-fiber nociceptors are present in vitro after plantar incision.

1 reference

12 December 2020

Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors

1 reference

12 December 2020

Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice.

1 reference

12 December 2020

GABA decreases in the spinal cord dorsal horn after peripheral neurectomy

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12 December 2020

State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain

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12 December 2020

An SCN9A channelopathy causes congenital inability to experience pain

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12 December 2020

Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons

1 reference

12 December 2020

Sensitization of nociceptive cutaneous nerve fibers from the rat's tail by noxious mechanical stimulation.

1 reference

12 December 2020

Increased calcitonin gene-related peptide immunoreactivity in gracile nucleus after partial sciatic nerve injury: age-dependent and originating from spared sensory neurons.

1 reference

12 December 2020

The cerebral signature for pain perception and its modulation

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12 December 2020

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

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12 December 2020

Peripheral axotomy induces only very limited sprouting of coarse myelinated afferents into inner lamina II of rat spinal cord

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12 December 2020

Painful neuropathy: altered central processing maintained dynamically by peripheral input

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12 December 2020

Na+ channel accumulation on axolemma of afferent endings in nerve end neuromas in Apteronotus

1 reference

12 December 2020

Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation

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12 December 2020

Neurotrophic factors and neuropathic pain

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12 December 2020

Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.

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12 December 2020

Sensory functions in chronic neuralgia

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12 December 2020

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

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12 December 2020

Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes

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12 December 2020

Patterned electrical activity modulates sodium channel expression in sensory neurons

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12 December 2020