Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene (Q28236533)

GOA release 2020-03-11

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14

M Tessier-Lavigne

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author name string

A Fazeli

1

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S L Dickinson

2

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M L Hermiston

3

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R V Tighe

4

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R G Steen

5

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C G Small

6

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E T Stoeckli

7

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K Keino-Masu

8

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M Masu

9

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H Rayburn

10

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J Simons

11

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R T Bronson

12

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J I Gordon

Identification of a chromosome 18q gene that is altered in colorectal cancers

13

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language of work or name

English

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publication date

24 April 1997

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published in

Nature

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volume

386

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page(s)

796-804

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issue

6627

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cites work

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7 January 2021

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

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Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression.

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Genetic alterations during colorectal-tumor development

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Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18

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Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer

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The DCC gene: structural analysis and mutations in colorectal carcinomas

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Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

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Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

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Chemotropic guidance of developing axons in the mammalian central nervous system

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The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.

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Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

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7 January 2021

Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system

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UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans.

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Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans.

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Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons.

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Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologs.

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7 January 2021

UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues

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frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance.

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Transgenesis by means of blastocyst-derived embryonic stem cell lines

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A genetic model for colorectal tumorigenesis

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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

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The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system

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A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18

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Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse.

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Suppression of intestinal neoplasia by DNA hypomethylation.

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Cell lineage-specific and differentiation-dependent patterns of CCAAT/enhancer binding protein alpha expression in the gut epithelium of normal and transgenic mice

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Spatial differentiation of the intestinal epithelium: analysis of enteroendocrine cells containing immunoreactive serotonin, secretin, and substance P in normal and transgenic mice

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The DCC gene product in cellular differentiation and colorectal tumorigenesis

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Paneth cell differentiation in the developing intestine of normal and transgenic mice

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The differentiating intestinal epithelial cell: establishment and maintenance of functions through interactions between cellular structures

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Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated

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In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death

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Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons

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DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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The likeness of being: phylogenetically conserved molecular mechanisms of growth cone guidance

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Production of homozygous mutant ES cells with a single targeting construct

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Axonin-1, Nr-CAM, and Ng-CAM play different roles in the in vivo guidance of chick commissural neurons

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7 January 2021

Identifiers

DOI

10.1038/386796A0

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1377985

1042406256

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1377985

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference