Platelet integrin alpha(IIb)beta(3): activation mechanisms (Q28236789)

Journal of Thrombosis and Haemostasis

Europe PubMed Central

title

Platelet integrin alpha(IIb)beta(3): activation mechanisms (English)

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author name string

Y-Q Ma

series ordinal

1

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J Qin

series ordinal

2

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E F Plow

series ordinal

3

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language of work or name

English

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publication date

July 2007

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published in

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volume

5

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issue

7

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page(s)

1345-52

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cites work

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Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes

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A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit

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Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits

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The PTB domain: a new protein module implicated in signal transduction

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An interaction between alpha-actinin and the beta 1 integrin subunit in vitro

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Sequence and domain structure of talin

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Focal adhesions, contractility, and signaling

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Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

21 April 2017

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The phosphotyrosine binding-like domain of talin activates integrins

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Structural determinants of integrin recognition by talin

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Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides

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Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

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Integrins: bidirectional, allosteric signaling machines

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Platelet glycoprotein IIb/IIIa receptors and Glanzmann's thrombasthenia

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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

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Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

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Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization

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Functional and structural correlations of individual alphaIIbbeta3 molecules

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A redox site involved in integrin activation

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Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state

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Membrane-mediated structural transitions at the cytoplasmic face during integrin activation

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A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

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Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

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Integrin cytoplasmic domains mediate inside-out signal transduction

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The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.

21 January 2018

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Suppression of integrin activation by the membrane-distal sequence of the integrin alphaIIb cytoplasmic tail

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A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation.

21 January 2018

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A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains

21 January 2018

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Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function

21 January 2018

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Soluble CD40 ligand induces β 3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling

21 January 2018

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Characterization of lysosomal acid lipase by site-directed mutagenesis and heterologous expression

21 January 2018

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Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.

21 January 2018

1 reference

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Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets

21 January 2018

1 reference

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The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation

21 January 2018

1 reference

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Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit.

21 January 2018

1 reference

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Localization of an integrin binding site to the C terminus of talin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2007.02537.X

Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1538-7836.2007.02537.X

The behavior of calpain-generated N- and C-terminal fragments of talin in integrin-mediated signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1538-7836.2007.02537.X

Bidirectional signaling between the cytoskeleton and integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2007.02537.X

The molecular basis of filamin binding to integrins and competition with talin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2007.02537.X

Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1538-7836.2007.02537.X

Complementation of dominant suppression implicates CD98 in integrin activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2007.02537.X

Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2007.02537.X

A conserved sequence motif in the integrin beta3 cytoplasmic domain is required for its specific interaction with beta3-endonexin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2007.02537.X

Conformational regulation of integrin structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2007.02537.X