The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways (Q28236956)

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scientific article (publication date: 21 July 2006)

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English	The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways	scientific article (publication date: 21 July 2006)

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20 January 2020

The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways (English)

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20 January 2020

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Gwénola Boulday

2

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20 January 2020

Thibaut Quillard

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Beatrice Charreau

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Juliette Fitau

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Flora Coulon

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27 April 2006

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20 January 2020

Journal of Biological Chemistry

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20 January 2020

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20 January 2020

20148-20159

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Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase

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Characterization of Lnk. An adaptor protein expressed in lymphocytes

1 reference

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Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice

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Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis

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Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways

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Acute activation of Erk1/Erk2 and protein kinase B/akt proceed by independent pathways in multiple cell types.

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

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CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. A target of interleukin (il)-4 and il-10 anti-inflammatory action

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Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha

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21 January 2018

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10.1074/JBC.M510997200

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20 January 2020

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20 January 2020

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