The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor (Q28238069)

A receptor-mediated pathway for cholesterol homeostasis

Europe PubMed Central

title

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor (English)

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2

J L Goldstein

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author name string

M S Brown

series ordinal

1

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language of work or name

English

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publication date

2 May 1997

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published in

Cell

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volume

89

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page(s)

331-40

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issue

3

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cites work

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Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene

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Loss of transcriptional activation of three sterol-regulated genes in mutant hamster cells

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Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

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Molecular cloning and functional analysis of the promoter of the human squalene synthase gene

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Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection

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Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

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Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

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Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain

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SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein

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Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.

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Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

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SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

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Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

37595

37595

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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